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REC8 encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. Additionally we are shipping REC8 Proteins (5) and REC8 Kits (3) and many more products for this protein.
Showing 10 out of 70 products:
Cow (Bovine) Polyclonal REC8 Primary Antibody for WB - ABIN2783199
Xu, Beasley, Warren, van der Horst, McKay: Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis. in Developmental cell 2005
Human Polyclonal REC8 Primary Antibody for WB - ABIN657493
Aston, Krausz, Laface, Ruiz-Castané, Carrell: Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. in Human reproduction (Oxford, England) 2010
We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 (show RNF212 Antibodies) influence genome-wide recombination rate, while genetic variants in PRDM9 (show PRDM9 Antibodies) influence genome-wide hotspot usage.
Rec8 establishes cohesion when activated during DNA replication in fetal oocytes using tamoxifen-inducible Cre. In contrast, no new cohesion is detected when Rec8 is activated in arrested oocytes by tamoxifen despite cohesin synthesis.
Plk1 (show PLK1 Antibodies) activity is required for meiotic spindle assembly and REC8 cleavage, with pPlk1Ser137 being the action executor, in mouse oocytes during meiotic division.
effects ofAte1ablation are inferred to be caused, at least in part, by the failure to destroy the C-terminal fragment of Rec8 in the absence of N-terminal arginylation.
Our findings strengthen the importance of RA and Dazl (show DAZL Antibodies) in the meiotic transition, provide important details about the Stra8 (show STRA8 Antibodies) pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function
STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions.
Findings indicate that cohesin-mediated long-range interactions facilitate discrete gene expression states within preexisting chromosomal compartments.
Data show that nociceptin (show PNOC Antibodies) induces Rec8 phosphorylation, triggering chromosome dynamics, in spermatocytes during meiosis in postnatal testes.
We report here evidence from the mouse that partial loss of gene function for either Smc1b (show SMC1B Antibodies) or Rec8 causes perturbations in the formation of the synaptonemal complex (SC) and affects both synapsis and recombination between homologs during meiotic prophase
show that spermatocytes from mice lacking the two meiosis-specific cohesin subunits RAD21L and REC8 were unable to initiate RAD51 (show RAD51 Antibodies)- but not DMC1 (show DMC1 Antibodies)-mediated double-strand break repair
Separase (show ESPL1 Antibodies) is regulated by two independent mechanisms in meiosis I, binding to securin (show PTTG1 Antibodies) and inhibitory phosphorylation by CDK1 (show CDK1 Antibodies); both must be disrupted to have any effect on either chromosome-associated REC8 levels or premature chromosome separation.
REC8 being a novel major bona fide tumor suppressor gene and a robust epigenetic target of the PI3K (show PIK3CA Antibodies) pathway. Aberrant inactivation of REC8 through hypermethylation by the PI3K (show PIK3CA Antibodies) pathway may represent an important mechanism mediating the oncogenic functions of the PI3K (show PIK3CA Antibodies) pathway
Indicate that polymorphisms of the Rec 8 gene are not a common cause of severe male factor infertility.
Data show that REC8 is constitutively expressed in tumour cells, along with SGOL1 (show SGOL1 Antibodies) and SGOL2 (show SGOL2 Antibodies), and that REC8 becomes modified after irradiation.
The mouse ortholog of REC8L1 is required for proper synapsis of homologous chromosomes during meiosis
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
REC8 homolog (yeast)
, meiotic recombination protein REC8 homolog
, REC8-like 1
, cohesin Rec8p
, meiotic cohesion Rec8
, REC8 homolog
, cohesion rec8p
, human homolog of rad21, S. pombe
, meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family
, meiotic recombination protein REC8-like 1
, recombination and sister chromatid cohesion protein homolog
, meiosis specific sister chromatid cohesion protein