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RBM10 encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. Additionally we are shipping RBM10 Antibodies (44) and many more products for this protein.
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RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5 (show RBM5 Proteins)) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD).
results provide evidence that RBM10 expression, in RBM5 (show RBM5 Proteins)-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 and RBM5 (show RBM5 Proteins) expression in clinical samples may therefore hold prognostic and/or potentially predictive value
RBM10-TFE3 (show TFE3 Proteins) is a recurrent gene fusion in Xp11 translocation renal cell carcinoma (show MOK Proteins).
Xp11 translocation renal cell carcinomas with RBM10-TFE3 (show TFE3 Proteins) gene fusion demonstrating melanotic features and overlapping morphology with t(6;11) RCC (show XRCC1 Proteins).
RBM10-TFE3 (show TFE3 Proteins) fusion variant (from chromosome X paracentric inversion), therefore, appears to be a recurrent molecular event in Xp11.2 RCCs. RBM10-TFE3 (show TFE3 Proteins) fusion should be added in the list of screened fusion transcripts in targeted molecular diagnostic multiplex RT-PCR
RBM10 is a tumor suppressor that represses Notch (show NOTCH1 Proteins) signaling and cell proliferation through the regulation of NUMB (show NUMB Proteins) alternative splicing
Src (show SRC Proteins) family tyrosine kinase (show TXK Proteins) signaling may regulate FilGAP (show ARHGAP24 Proteins) through association with RBM10
The ability of RBM10v1 to regulate alternative splicing depends, at least in part, on a structural alteration within the second RNA recognition motif domain, and correlates with preferential expression of the NUMB (show NUMB Proteins) exon 11 inclusion variant.
RBM10 regulates alternative splicing of Fas (show FAS Proteins) and Bcl-x (show BCL2L1 Proteins) genes.
Antagonizes the effects of RBM5 (show RBM5 Proteins), RBM6 (show RBM6 Proteins), and RBM10 in cell colony formation.
These results demonstrate a role for RBM10 in the regulation of alternative splicing in two cell models of mouse early development and suggests that mutations in RBM10 could lead to splicing changes that affect normal palate development and cause human disease.
Expression of Rbm5 (show RBM5 Proteins) and Rbm10 RNA remained constant during C2C12 myogenesis, but protein levels significantly decreased.
S1-1 constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner; upon globally reducing RNA polymerase II transcription, S1-1 nuclear bodies enlarge and decrease in number.
This gene encodes a nuclear protein that belongs to a family proteins that contain an RNA-binding motif. The encoded protein associates with hnRNP proteins and may be involved in regulating alternative splicing. Defects in this gene are the cause of the X-linked recessive disorder, TARP syndrome. Alternate splicing results in multiple transcript variants.
RNA binding motif protein 10
, RNA-binding protein 10-like
, RNA-binding protein 10
, RNA-binding protein S1-1
, g patch domain-containing protein 9
, RNA-binding motif protein 10
, S1-1 protein from liver