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Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005. Additionally we are shipping and many more products for this protein.
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The authors demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 (PRMT1 (show PRMT1 Antibodies)) at residue R578, leading to its degradation via ubiquitylation by an E3 ligase (CNOT4 (show CNOT4 Antibodies)).
OTT1 regulates the alternative splicing of Mpl- (show MPL Antibodies)TR, a truncated isoform of c-Mpl, (show MPL Antibodies) which modulates Thrombopoietin- (show THPO Antibodies)mediated signaling.
RBM15 does indeed play a critical role in the survival of chronic myelogenous leukemia (CML) cells, which may have potential application in designing molecular therapies for CML treatment.
both Rbm15 and the leukemogenic Rbm15-Mkl1 (show MKL1 Antibodies) fusion protein interact with the Setd1b (show SETD1B Antibodies) histone H3 (show HIST3H3 Antibodies)-Lys4 methyltransferase
A four-way variant translocation originating the RBM15-MKL1 (show MKL1 Antibodies) fusion gene is associated with acute megakaryoblastic leukemia.
HHV-8 ORF57 interacts with RBM15 and OTT3 (show RBM15B Antibodies) to promote expression of viral intronless genes.
Fusion with MKL1 (show MKL1 Antibodies) protein in acute myeloid leukemi.
functional and spatial changes of OTT and BSAC (show MKL1 Antibodies) caused by the fusion might perturb their functions, culminating in the development of acute megakaryoblastic leukemia.
The deregulated activation of MAL-dependent and -independent promoters results in tissue-specific functions of OTT-MAL.[OTT-MAL]
Rbm15 is required for Xist-mediated silencing. Rbm15 is important for efficient deposition of H3K27me3 on the inactive chromosome.
Rbm15 regulates the alternative splicing of Mpl (show MPL Antibodies)-TR, a truncated isoform of c-Mpl (show MPL Antibodies), which modulates Thrombopoietin (show THPO Antibodies)-mediated signaling.
Rbm15 is differentially expressed during hematopoiesis and may act to inhibit myeloid differentiation in hematopoietic cells via a mechanism that is mediated by stimulation of Notch (show NOTCH1 Antibodies) signaling via RBPJkappa.
Rbm15 has pleiotropic roles in hematopoietic development.
c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development.
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005
RNA binding motif protein 15
, putative RNA-binding protein 15-like
, RNA-binding motif protein 15
, one twenty two protein
, one twenty-two
, one-twenty two protein 1
, putative RNA-binding protein 15