RBM15 antibody

Catalog No. ABIN7246706

Product Details anti-RBM15 Antibody

Target: RBM15 (RNA Binding Motif Protein 15 (RBM15))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM15 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human RBM15

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:300, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.2 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RBM15

Target: RBM15 (RNA Binding Motif Protein 15 (RBM15))

Alternative Name: RBM15 (RBM15 Products)

Synonyms: MGC83913 antibody, im:7139999 antibody, OTT antibody, OTT1 antibody, SPEN antibody, C230088J01Rik antibody, mKIAA1438 antibody, RNA binding motif protein 15 antibody, RNA binding motif protein 15 S homeolog antibody, RBM15 antibody, rbm15.S antibody, rbm15 antibody, Rbm15 antibody

Background: RNA-binding motif protein 15 (RBM15) belongs to the SPEN protein family,which have repressor function in several signaling pathway,and may bind to RNA through interaction with spliceosome components. It was first described as a 5' translocation partner of the MAL gene in t(1,22)(p13,q13) infant acute megakaryocytic leukemia,and it functions in murine hematopoiesis through modulating Notch-induced transcriptional activation,which play crucial roles in leukemogenesis. Decreasing RBM15 levels with RNA interference could inhibit the growth and proliferation,block the cell cycle,and induce apoptosis in CML cells.

UniProt: Q96T37