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RBM3 is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Additionally we are shipping RBM3 Antibodies (64) and RBM3 Proteins (15) and many more products for this protein.
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Studies showed RBM3 as one of the important cold shock protein with critical roles in rapid cell adaption to the alterations of the environmental stress. Also, RBM3 plays an important role in neuroprotection, anti-apoptotic functions, cell proliferation as well as its function as proto-oncogene (show RAB1A ELISA Kits).[review]
The results indicate the existence of a negative feedback loop that regulates fever via reduced RBM3 levels and increased expression of miR (show MLXIP ELISA Kits)-142-5p and miR (show MLXIP ELISA Kits)-143.
Low RBM3 immunoexpression is associated with urothelial carcinoma of the bladder.
RBM3 may be a potential biomarker for treatment stratification in patients with metastatic non-seminomatous germ cell tumours.
High RBM3 expression is an independent prognostic marker in prostate cancer.
The data suggest that the overexpression of RBM3 may serve as an important molecular mechanism underlying astrocytic carcinogenesis.
A novel role of RBM3 in linking stress-regulated RNA splicing to tumorigenesis.
Loss of RBM3 expression is associated with more aggressive tumors and poorer prognosis of urothelial bladder cancer. Findings may indicate that loss of RBM3 expression results in a phenotype more prone to metastatic spread than local aggressiveness.
the inverse association and prognostic impact of MCM3 (show MCM3 ELISA Kits) and RBM3 expression indicate a possible interaction of these proteins in melanoma progression
high tumor-specific nuclear expression of RBM3 is an independent predictor of good prognosis in colorectal cancer
deficient synapse regeneration, mediated at least in part by failure of the RBM3 stress response, contributes to synapse loss throughout the course of neurodegenerative disease
Moderate hypothermia resulted in significant up-regulation of both RBM3 and CIRP (show CIRBP ELISA Kits) mRNA in murine organotypic hippocampal slice cultures
Up-regulation of neuronal RBM3 apparently accounts for a substantial proportion of hypothermia-induced neuroprotection in the developing postnatal murine brain.
Overexpression of RBM3 in skeletal muscle myoblasts is associated with an increase in cell survival through inhibitory actions on both apoptosis and necrosis.
Rbm3(-/-) mouse embryonic fibroblasts have markedly increased number of G2-phase cells, suggesting a hitherto unknown role of RBM3 in the G2-phase control.
Data suggest that both Rbm3 and microRNAs are part of a homeostatic mechanism that regulates global levels of protein synthesis under normal and cold-stress conditions.
the RNA stabilizing and translation regulatory protein (show TGFB1 ELISA Kits) RBM3 is a novel proto-oncogene (show RAB1A ELISA Kits) that induces transformation when overexpressed and is essential for cells to progress through mitosis.
This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria.
RNA-binding motif protein 3
, putative RNA-binding protein 3
, RNA binding motif protein 3