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Putative signaling adapter which may play a role in neuronal differentiation. Additionally we are shipping RUN and SH3 Domain Containing 1 Antibodies (31) and many more products for this protein.
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RUN domain of NESCA can bind H-Ras (show HRAS Proteins), a downstream signaling molecule of TrkA (show NTRK1 Proteins), with high affinity. Moreover, NESCA RUN can directly interact with TrkA (show NTRK1 Proteins).
Nesca functions as an adapter involved in neuronal vesicular transport
Data show that NESCA and NEMO (show IKBKG Proteins) interact by their N-terminal region, that NESCA directly associates with TRAF6 (show TRAF6 Proteins), which in turn catalyzes NESCA polyubiquitination, and that NESCA overexpression strongly inhibits TRAF6 (show TRAF6 Proteins)-mediated polyubiquitination of NEMO (show IKBKG Proteins).
Data suggest that Nesca serves a novel, nuclear-dependent role in neurotrophin (show BDNF Proteins)-dependent neurite outgrowth.
Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK (By similarity).
RUN and SH3 domain containing 1
, RUN and SH3 domain-containing protein 1
, new molecule containing SH3 at the carboxy-terminus