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Ras Homolog Gene Family, Member J Proteins (RHOJ)

RHOJ encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). Additionally we are shipping Ras Homolog Gene Family, Member J Antibodies (51) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RHOJ 57381 Q9H4E5
Rat RHOJ RHOJ 299145  
RHOJ 80837 Q9ER71
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Top Ras Homolog Gene Family, Member J Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RHOJ Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Ras Homolog Gene Family, Member J (RHOJ) Interaction Partners

Human Ras Homolog Gene Family, Member J (RHOJ) interaction partners

  1. FMNL3 interacts with Cdc42 and RhoJ, two Rho family GTPases known to be required for lumen formation. FMNL3 and RhoJ are concentrated at the early apical surface, or AMIS, and regulate the formation of radiating actin cables from this site.

  2. RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility.

  3. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects.

  4. These observations identify RHOJ as a melanoma linchpin determinant that regulates both actin cytoskeletal dynamics and chemoresistance by activating PAK1 (show PAK1 Proteins).

  5. Arhgef15 acts as an endothelial cell-specific GEF to mediate VEGF-induced Cdc42 activation and potentiate RhoJ inactivation, thereby promoting actin polymerization and cell motility.

  6. we identified RhoJ and its effector PAK1 (show PAK1 Proteins), as key modulators of melanoma cell sensitivity to DNA damage

  7. Our study supports a novel role for the Rho family member RhoJ in ednothelial cell morphogenesis and in particular in lumen formation

  8. RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers.

  9. TCL is essential for clathrin-dependent endocytosed receptors to enter the early/sorting endosomes

Mouse (Murine) Ras Homolog Gene Family, Member J (RHOJ) interaction partners

  1. RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility.

  2. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects.

  3. RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers.

  4. The results strongly suggest that TCL/TC10betaL regulates adipocyte differentiation by controlling mitotic clonal expansion and this regulatory effect is closely linked to C/EBPbeta (show CEBPB Proteins) and C/EBPdelta (show CEBPD Proteins) expression.

  5. TCL/TC10betaL has a crucial role in the early stage of adipocyte differentiation, is probably linked to the PPARgamma (show PPARG Proteins) pathway, and up-regulates epression of genes associated with adipogenesis.

  6. Insulin (show INS Proteins) induces phosphatidylinositol 3-phosphate formation through TC10 (show RHOQ Proteins) activation.

Ras Homolog Gene Family, Member J (RHOJ) Protein Profile

Protein Summary

This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis.

Gene names and symbols associated with RHOJ

  • ras homolog gene family, member J (RHOJ)
  • ras homolog gene family, member J (rhoj)
  • ras homolog family member J (RHOJ)
  • ras homolog family member J (rhoj)
  • ras homolog gene family, member J (LOC100350942)
  • ras homolog family member J (Rhoj)
  • ras homolog gene family, member J (Rhoj)
  • 1110005O19Rik protein
  • Arhj protein
  • AW210585 protein
  • MGC83410 protein
  • RASL7B protein
  • RHOJ protein
  • si:dkey-100h21.1 protein
  • TC10B protein
  • TC10L protein
  • TCL protein

Protein level used designations for RHOJ

ras homolog gene family, member J , TC10-like Rho GTPase , rho-related GTP-binding protein RhoJ , RAS-like, family 7, member B , ras-like protein family member 7B , tc10-like GTP-binding protein , tc10-like GTP-binding protein TCL

GENE ID SPECIES
423513 Gallus gallus
444554 Xenopus laevis
452960 Pan troglodytes
540619 Bos taurus
556371 Danio rerio
612985 Canis lupus familiaris
705603 Macaca mulatta
100125013 Xenopus (Silurana) tropicalis
100155474 Sus scrofa
100350942 Oryctolagus cuniculus
57381 Homo sapiens
299145 Rattus norvegicus
80837 Mus musculus
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