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RGS7BP encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. Additionally we are shipping and many more products for this protein.
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BL3-ht2 of RGS7BP may be an important genetic variant associated with AERD. The haplotype of block 3 may play a protective role against aspirin hypersensitivity in asthma, perhaps by altering the responsiveness of muscarinic receptors.
cytoplasmic RGS7*Gbeta5 (show GNB5 Proteins)*R7BP heterotrimers and RGS7*Gbeta5 (show GNB5 Proteins) heterodimers are equivalently inefficient regulators of G protein-coupled receptor (show ADRA1A Proteins) signaling relative to plasma membrane-bound heterotrimers bearing palmitoylated R7BP.
the successful purification of functionally intact Gbeta5 (show GNB5 Proteins)-free recombinant RGS11 (show RGS11 Proteins) was reported that differentially interact with R7BP and Galpha (show SUCLG1 Proteins)(oa).
R7BP-dependent regulation of R7-RGS (show PITX2 Proteins) proteins shapes specific aspects of light-evoked and spontaneous activity of retinal ganglion cells in mature and developing retina.
GIRK modulation occurs by channel assembly with R7-RGS (show PITX2 Proteins)/Gbeta5 (show GNB5 Proteins) complexes under allosteric control of R7 RGS (show PITX2 Proteins)-binding protein (R7BP).
R7BP is a negative modulator of the analgesic and locomotor activating actions of morphine that contributes to the development of morphine tolerance.
regulator of G-protein signalling 7 binding protein contributes significantly to the nuclear localization of endogenous G beta(5)/R7-RGS (show PITX2 Proteins) complex in brain
These results indicate that dopamine signaling in the striatum is controlled by concerted interplay between two RGS (show PITX2 Proteins) proteins, RGS7 and RGS9-2 (show RGS Proteins), which are balanced by a common subunit, R7BP.
All four R7 RGS (show PITX2 Proteins) proteins co-precipitate with R7BP from brain extracts and recombinant R7 proteins bind recombinant R7BP with high efficiency
Review. R7BP transduces signals directly from receptors and G proteins at the plasma membrane to the nucleus, and this plasma membrane-nuclear shuttling is controlled by reversible palmitoylation of R7BP.
R7BP controls expression of regulator of G-protein signaling (RGS)9-2 expression at the posttranslational level.
R7-Gbeta5 (show GNB5 Proteins)-R7BP complexes in the mouse could regulate signaling by modulatory Gi/o-coupled GPCRs in the developing and adult nervous systems.
Delivery of RGS7/Gbeta5 (show GNB5 Proteins) to dendrites of ON-bipolar cells occurs independently of its association with R7BP. These findings provide a new mechanism for adapter-independent targeting of RGS (show PITX2 Proteins)/Gbeta5 (show GNB5 Proteins) complexes.
This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
R7 family-binding protein
, regulator of G-protein signaling 7-binding protein
, R7 binding protein