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Regulator of G-Protein Signaling 10 Proteins (RGS10)

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. Additionally we are shipping RGS10 Antibodies (40) and RGS10 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RGS10 6001 O43665
RGS10 54290  
RGS10 67865 Q9CQE5
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Top RGS10 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,069.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,427.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RGS10 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

Top referenced RGS10 Proteins

  1. Human RGS10 Protein expressed in Escherichia coli (E. coli) - ABIN667506 : Cali, Balcueva, Rybalkin, Robishaw: Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning. in The Journal of biological chemistry 1992 (PubMed)
    Show all 2 references for ABIN667506

  2. Human RGS10 Protein expressed in Wheat germ - ABIN1317922 : Rivero, Gabilondo, García-Sevilla, La Harpe, Morentín, Javier Meana: Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain. in Neurochemistry international 2010 (PubMed)

More Proteins for Regulator of G-Protein Signaling 10 (RGS10) Interaction Partners

Human Regulator of G-Protein Signaling 10 (RGS10) interaction partners

  1. RGS10 plays a role in chemoresistance in ovarian cancer. Loss of RGS10 enhances survival among these cells.

  2. RGS10 could serve in a novel, and previously unknown, role by accelerating the hydrolysis of GTP (show AK3 Proteins) from Rheb (show RHEB Proteins) in ovarian cancer cells.

  3. Inhibition of HDAC1 (show HDAC1 Proteins) and DNMT1 (show DNMT1 Proteins) modulate RGS10 expression and decrease ovarian cancer chemoresistance.

  4. The results suggest unaltered membrane RGS4 (show RGS4 Proteins) and cytosolic RGS10 proteins levels in schizophrenia and major depression.

  5. Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.

  6. RGS10 is a key molecule that contributes to the inhibition of Galpha (show SUCLG1 Proteins)-dependent signaling during chemokine (show CCL1 Proteins)-activated alpha4beta1- and alphaLbeta2-dependent T cell adhesion.

  7. RGS10 and RGS4 (show RGS4 Proteins) proteins are both detected in postmortem prefrontal cortex.

  8. Results establish RGS10 and RGS17 (show RGS17 Proteins) as novel regulators of cell survival and chemoresistance in ovarian cancer cells and suggest that their reduced expression may be diagnostic of chemoresistance.

  9. Results demonstrate the specificity of RGS10A as a key component in the RANKL (show TNFSF11 Proteins)-evoked signaling pathway for osteoclast differentiation.

Mouse (Murine) Regulator of G-Protein Signaling 10 (RGS10) interaction partners

  1. These data demonstrate a critical role for RGS10 in mediating autoimmune disease through regulation of T lymphocyte function.

  2. data indicate that Rgs10-/- macrophages displayed dysregulated M1 responses along with blunted M2 alternative activation responses

  3. we identified protein kinase A and the downstream phospho-cAMP response element-binding signaling pathway as key mediators of the neuroprotective effect of RGS10 against inflammatory stress

  4. RGS10 negatively regulates nuclear factor kappaB activation and production pathway in microglia and demonstrates the neuroprotective effects of microglial RGS10 gene transfer in a rat model of parkinsonism.

  5. mechanism through which RGS10 specifically regulates the RANKL (show TNFSF11 Proteins)-evoked RGS10/calmodulin (show Calm2 Proteins)-[Ca2 (show CA2 Proteins)+]i oscillation-calcineurin (show PPP3CA Proteins)-NFATc1 (show NFATC1 Proteins) signaling pathway in osteoclast differentiation

  6. Results demonstrate the specificity of RGS10A as a key component in the RANKL (show TNFSF11 Proteins)-evoked signaling pathway for osteoclast differentiation.

  7. Limits microglial-derived TNF (show TNF Proteins) secretion and regulates functional outcome of inflammatory stimuli in tventral midbrain. Novel drug target for prevention of nigrostriatal pathway degeneration, neuropathological hallmark of Parkinson's disease.

RGS10 Protein Profile

Protein Summary

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RGS10

  • regulator of G-protein signalling 10 (RGS10)
  • regulator of G-protein signaling 10 (rgs10)
  • regulator of G-protein signaling 10 (RGS10)
  • regulator of G-protein signaling 10 (Rgs10)
  • regulator of G-protein signalling 10 (Rgs10)
  • 2310010N19Rik protein
  • MGC82511 protein
  • RGS10 protein

Protein level used designations for RGS10

regulator of G-protein signalling 10 , regulator of G-protein signaling 10

GENE ID SPECIES
423930 Gallus gallus
444003 Xenopus laevis
477840 Canis lupus familiaris
496908 Xenopus (Silurana) tropicalis
703125 Macaca mulatta
6001 Homo sapiens
448968 Sus scrofa
614550 Bos taurus
54290 Rattus norvegicus
67865 Mus musculus
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