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Regulator of G-Protein Signalling 18 Proteins (RGS18)

RGS18 encodes a member of the regulator of G-protein signaling family. Additionally we are shipping RGS18 Antibodies (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RGS18 64407 Q9NS28
RGS18 64214 Q99PG4
RGS18 289076 Q4L0E8
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Top RGS18 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,594.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details

RGS18 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Regulator of G-Protein Signalling 18 (RGS18) Interaction Partners

Human Regulator of G-Protein Signalling 18 (RGS18) interaction partners

  1. These findings indicate cross-talk between platelet activation and inhibition pathways at the level of RGS18 and Gq.

  2. Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.

  3. molecular cloning and characterization of RGS18 as a regulator of G protein signalling in human platelets

Mouse (Murine) Regulator of G-Protein Signalling 18 (RGS18) interaction partners

  1. these results identify Rgs18 as a new and crucial effector of Gfi1b (show GFI1B Proteins) that regulates downstream signaling and gene expression programs to orchestrate erythro-megakaryocytic lineage choices.

  2. Regulator of G-protein signaling 18 controls both platelet generation and function.

  3. Regulated sequestration and release of RGS18 by intracellular binding proteins coordinates activating and inhibitory signaling networks in platelets. Substituting alanine for Ser94 blocks cAMP-induced dissociation of the SPL/RGS/SHP-1 complex.

  4. RGS18 deficiency markedly shortened bleeding as well as occlusion times (in vivo). Furthermore, RGS18(-/-) platelets displayed hyper-responsiveness with regards to agonist induced aggregation

  5. study is the first to show that RGS18 regulates megakaryopoiesis but also reveals its unexpected role in ciliogenesis, at least in lower vertebrates, via interference with Wnt (show WNT2 Proteins) signaling.

  6. RGS18 acts as a negative regulator of the acidosis-induced osteoclastogenic protein-coupled receptor 68/NFAT (show NFATC1 Proteins) signaling pathway

RGS18 Protein Profile

Protein Summary

This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Gene names and symbols associated with RGS18

  • regulator of G-protein signaling 18 (RGS18)
  • regulator of G-protein signalling 18 (rgs18)
  • regulator of G-protein signalling 18 (LOC100224724)
  • regulator of G-protein signalling 18 (LOC100350029)
  • regulator of G-protein signaling 18 (Rgs18)
  • RGS13 protein
  • rgs18 protein

Protein level used designations for RGS18

regulator of G-protein signalling 18 , regulator of G-protein signaling 18 , regulator of G-protein signalling 13

GENE ID SPECIES
424361 Gallus gallus
457592 Pan troglodytes
100136669 Oncorhynchus mykiss
100224724 Taeniopygia guttata
100350029 Oryctolagus cuniculus
64407 Homo sapiens
64214 Mus musculus
289076 Rattus norvegicus
607858 Canis lupus familiaris
613624 Bos taurus
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