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A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS\; MIM 209920). Additionally we are shipping RFX5 Proteins (5) and many more products for this protein.
Showing 10 out of 90 products:
Human Polyclonal RFX5 Primary Antibody for WB - ABIN2780343
Xu, Farmer, Smith: Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression. in The Journal of biological chemistry 2007
Human Polyclonal RFX5 Primary Antibody for EMSA, EIA - ABIN116534
Steimle, Durand, Barras, Zufferey, Hadam, Mach, Reith: A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). in Genes & development 1995
Human Polyclonal RFX5 Primary Antibody for GS, WB - ABIN106544
Xu, Sengupta, Seto, Smith: Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression. in The Journal of biological chemistry 2006
Human Polyclonal RFX5 Primary Antibody for WB - ABIN657925
Laird, Briggs, Boss, Summers, Garvie: Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex. in Journal of molecular biology 2010
Dog (Canine) Polyclonal RFX5 Primary Antibody for WB - ABIN2780342
Nagarajan, Long, Harreman, Corbett, Boss: A hierarchy of nuclear localization signals governs the import of the regulatory factor X complex subunits and MHC class II expression. in Journal of immunology (Baltimore, Md. : 1950) 2004
Data show arginine methyltransferase PRMT6 (show PRMT6 Antibodies) methylates the AT-hook motif of regulatory factor RFX5 and downregulates HLA-DQ expression.
these data have identified as novel pathway whereby SIRT1 (show SIRT1 Antibodies) maintains COL1A2 (show COL1A2 Antibodies) synthesis in SMCs by modulating RFX5 activity.
RFXAP (show RFXAP Antibodies)(C) consists of two alpha-helices that form a V-shaped structure that packs within the RFX5(N)(2) staple.
interaction at COL1A2 (show COL1A2 Antibodies) start site and transcription repression
The mutation for the fifth Bbare lymphocyte syndrome complementation group was found in RFX5 and was mapped to one of the arginines in a DNA-binding surface of this protein. Its wild-type counterpart restored function.
RFX5 binds to the collagen transcription start site and represses collagen gene expression
The identification of nuclear import and export sites on RFX molecules provides potential targets to modulate MHC class II expression.
results demonstrate that RFX1 (show RFX1 Antibodies) and RFX5 differentially interact with class I HDACs underlying the different pathways when repressing collagen synthesis
PPARgamma (show PPARG Antibodies) is within the RFX5.CIITA (show CIITA Antibodies) complex as judged by co-immunoprecipitation and DNA affinity precipitation studies
RFXAP (show RFXAP Antibodies) and RFXB (show RFXANK Antibodies) have roles in relieving autoinhibition of RFX5
TSA (show PRDX2 Antibodies) treatment enhances the association of CIITA (show CIITA Antibodies) with the transcription factor RFX5, which ameliorates the down-regulation of CIITA (show CIITA Antibodies) recruitment to target promoters by HDAC2 (show HDAC2 Antibodies).
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS\; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined.
DNA-binding protein RFX5
, regulatory factor X 5
, DNA-binding protein Rfx5
, regulatory factor X, 5
, regulator factor X 5