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Regulatory Factor X-Associated Protein Proteins (RFXAP)

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. Additionally we are shipping RFXAP Antibodies (48) and RFXAP Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RFXAP 5994 O00287
RFXAP 170767 Q8VCG9
Rat RFXAP RFXAP 499617  
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Top RFXAP Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

RFXAP Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Regulatory Factor X-Associated Protein (RFXAP) Interaction Partners

Human Regulatory Factor X-Associated Protein (RFXAP) interaction partners

  1. Data show a negative correlation between microRNA miR (show MLXIP Proteins)-212-3p and regulatory factor X-associated protein (RFXAP) in pancreatic cancer (PC) tissue.

  2. RFXAP(C) consists of two alpha-helices that form a V-shaped structure that packs within the RFX5 (show RFX5 Proteins)(N)(2) staple.

  3. Study demonstrates that coordinate loss of MHCII expression in OCI-Ly2 DLBCL cells is associated with an 11-base deletion in the cDNA encoding RFX-AP, that is required for activating MHCII transcription.

  4. The identification of nuclear import and export sites on RFX molecules provides potential targets to modulate MHC class II expression.

  5. Only the C-terminal half of the protein is conserved among vertebrates. The C-terminal third of RFXAP, with an extensive glutamine (show GFPT1 Proteins)-rich tract, could rescue HLA-DR, but not HLA-DQ or HLA-DP (show HLA-DPB1 Proteins) expression in a bare lymphocyte syndrome cell line.

  6. The transcriptional silent state of RFXAP correlated with reduced recruitment of RNA polymerase II to RFXAP chromatin in the MHC-II deficiency patient.

  7. RFXAP and RFXB (show RFXANK Proteins) have roles in relieving autoinhibition of RFX5 (show RFX5 Proteins)

  8. the interaction between RFX5 (show RFX5 Proteins) and RFXAP promote folding of a poorly structured region ofRFXAP, which is required for high affinity binding of RFXB (show RFXANK Proteins) to the RFX5 (show RFX5 Proteins).RFXAP complex

Mouse (Murine) Regulatory Factor X-Associated Protein (RFXAP) interaction partners

  1. Invitro transcription/translation and transfection studies described here show that non-AUG (ACG) codon functions as a translation initiation codon.

RFXAP Protein Profile

Protein Summary

Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene.

Gene names and symbols associated with RFXAP

  • regulatory factor X-associated protein (RFXAP)
  • regulatory factor X-associated protein (rfxap)
  • regulatory factor X-associated protein (Rfxap)
  • 5730495K23Rik protein
  • RFXAP protein

Protein level used designations for RFXAP

regulatory factor X-associated protein , RFX DNA-binding complex 36 kDa subunit , RFX-associated protein

GENE ID SPECIES
418899 Gallus gallus
540760 Bos taurus
607367 Canis lupus familiaris
694441 Macaca mulatta
100379771 Xenopus (Silurana) tropicalis
5994 Homo sapiens
170767 Mus musculus
499617 Rattus norvegicus
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