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Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. Additionally we are shipping and and many more products for this protein.
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Relaxin serves as a model for understanding lactocrine signals that support development of neonatal tissues.
Swine relaxin provides protection against ischemia-reperfusion-induced renal injury in rats by reducing apoptosis and inflammation.
Establishment of the neonatal porcine uterine developmental program requires maternal lactocrine support via relaxin.
Relaxin was detected in denuded oocytes, cumulus cells, mature boar spermatozoa, zygotes, and embryos (cleaved and blastocysts).
Exogenous relaxin influences its own receptors expression, improves oocyte nuclear maturation. Its beneficial effect on total cell number of blastocysts appears to be through a Bcl2 (show BCL2 ELISA Kits)-like1/Bax (show BAX ELISA Kits)-independent mechanism.
This study provides evidence for expression of RLN-RXFP1 (show RXFP1 ELISA Kits) ligand-receptor system in the boar testis, suggesting that the testes act as a source and possible target tissue of RLN.
Changes of relaxin mRNA are correlated with changes of the hormone in the CL during pregnancy, suggesting that the relaxin level is determined by the amount of mRNA available for translation.
Relaxin-producing C2C12 myoblasts displayed greater efficacy to engraft the post-ischaemic scar and to induce extracellular matrix re-modelling and angiogenesis as compared with the control cells
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.