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RGR encodes a putative retinal G-protein coupled receptor. Additionally we are shipping RGR Antibodies (51) and RGR Kits (3) and many more products for this protein.
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structure of rhodopsin and opsin dimer in native membranes
The role of Rgr using rgr-/- single and rdh5 (show RDH5 Proteins)-/-rgr-/- double knockout mice under a number of light conditions was studied; results suggest that RGR and RDH5 (show RDH5 Proteins) are likely to function in the retinoid cycle, although their role is not essential
RGR-opsin mediates light-dependent translocation of all-trans-retinyl esters from a storage pool in lipid droplets to an "isomerase pool" in membranes of the endoplasmic reticulum.
study to systemically analyze the potential role of variants of RGR in retinal diseases results of the suggested that the heterozygous truncation variants in RGR were less likely to be pathogenic
conclude that the ability of hRgr to activate both Ral and Ras is responsible for its transformation-inducing phenotype and it could be an important contributor in the development of some T-cell malignancies
It is likely that mutations in RGR, RBP3 (show E2F1 Proteins), and possibly RBP1 occur rarely in inherited retinal dystrophies.
E150K opsin is partially colocalized with the cis/medial Golgi compartment but not with the trans-Golgi network; results are consistent with recessive pattern of inheritance; retinal degeneration results from deficient export of opsin from the Golgi
These results indicate that after exon-skipping RGR splice isoform (RGR-d) is synthesized, the RGR-d epitope is released at the basal surface of the retinal pigment epithelium and deposited into Bruch's membrane in human eyes throughout adult life.
the exon-skipping variant of RGR (RGR-d) is found in extracellular deposits;at the base of early-stage drusen mounds in the older donors and may precede the formation of these drusen
This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.
RPE-retinal G protein-coupled receptor
, retinal g-protein receptor opsin
, rgr opsin
, retinal G protein coupled receptor
, retinal G-protein coupled receptor
, RGR opsin
, RPE retinal G-protein coupled receptor