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Retinol Dehydrogenase 10 (All-Trans) Proteins (RDH10)

RDH10 encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Additionally we are shipping Retinol Dehydrogenase 10 (All-Trans) Antibodies (46) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RDH10 157506 Q8IZV5
RDH10 98711 Q8VCH7
RDH10 353252 Q80ZF7
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Top Retinol Dehydrogenase 10 (All-Trans) Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,924.17
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Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,924.17
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Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,924.17
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RDH10 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Retinol Dehydrogenase 10 (All-Trans) (RDH10) Interaction Partners

Human Retinol Dehydrogenase 10 (All-Trans) (RDH10) interaction partners

  1. Insulin (show INS Proteins) inhibits retinoic acid biosynthesis through inhibition of FoxO1 (show FOXO1 Proteins)-induced Rdh10 gene expression.

  2. Data indicate that retinaldehyde reductase (DHRS3 (show DHRS3 Proteins)) requires retinol dehydrogenase 10 (RDH10) for full enzymatic activity and, in turn, activates RDH10.

  3. all three proteins (RDH10, RALDH2 (show ALDH1A2 Proteins), and CRABP2 (show CRABP2 Proteins)) appeared to be required for ATRA production induced by activation of PPARgamma (show PPARG Proteins)

  4. Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft culture.

  5. CYP4Z1 (show CYP4Z1 Proteins), KIR (show GEM Proteins) and RDH10 could play a role in non-small-cell lung cancer progression

  6. organization of the gene includes a unique transcriptional start site, a coding region with six translated exons and a 3' UTR containing at least two used polyadenylation sites.

  7. Forced over-expression of the RDH10 gene causes growth arrest of HepG2 cells and could be a possible curative strategy for hepatocellular carcinoma.

  8. dual physiological role for RDH10: in the biosynthesis of 11-cis (show CISH Proteins)-retinaldehyde for vision as well as the biosynthesis of all-trans-retinoic acid for differentiation and development

  9. wild-type RDH10 catalysed both oxidation of all-trans-retinol and reduction of all-trans-retinal in a cofactor-dependent manner In vitro, however, oxidation is the favoured reaction catalysed by RDH10

Mouse (Murine) Retinol Dehydrogenase 10 (All-Trans) (RDH10) interaction partners

  1. RDH10 acts in cooperation with other RDH isoforms to produce the 11-cis (show CISH Proteins)-retinal chromophore needed for vision.

  2. Insulin (show INS Proteins) inhibits retinoic acid biosynthesis through inhibition of FoxO1 (show FOXO1 Proteins)-induced Rdh10 gene expression.

  3. all three proteins (RDH10, RALDH2 (show ALDH1A2 Proteins), and CRABP2 (show CRABP2 Proteins)) appeared to be required for ATRA production induced by activation of PPARgamma (show PPARG Proteins)

  4. Rdh10-/- embryos demonstrate that RA controls hindbrain but not early forebrain patterning, while studies on retinaldehyde-rescued Rdh10-/- embryos show that meningeal RA synthesis is unnecessary to stimulate forebrain cortical expansion.

  5. Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males.

  6. retinol dehydrogenase (show ADH7 Proteins) Rdh10 localizes to lipid droplets during acyl ester biosynthesis

  7. RDH10-mediated oxidation of retinol plays as important a role in the control and regulation of retinoic acid production during embryogenesis as does the subsequent RALDH-mediated reaction.

  8. identified a missense mutation in the Rdh10 gene (Rdh10(m366Asp) ) using an N-ethyl-N-nitrosourea-induced forward genetic screen that result in reduced RA levels and signaling during embryonic development

  9. Retinol dehydrogenase 10 is involved in embryonic patterning and its loss of function can be rescued by maternal retinaldehyde treatment.

  10. Using protein modeling, enzymatic assays, and mutant embryos, we determined that RDH10(trex) mutant protein lacks the ability to oxidize retinol to retinal, resulting in insufficient retinoic acid signaling.

Retinol Dehydrogenase 10 (All-Trans) (RDH10) Protein Profile

Protein Summary

This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.

Gene names and symbols associated with RDH10

  • retinol dehydrogenase 10b (rdh10b)
  • retinol dehydrogenase 10 (MCYG_00691)
  • retinol dehydrogenase 10 (all-trans) (RDH10)
  • retinol dehydrogenase 10 (all-trans) (Rdh10)
  • 3110069K09Rik protein
  • 4921506A21Rik protein
  • AI875664 protein
  • AW549993 protein
  • cb804 protein
  • D1Ertd762e protein
  • m366Asp protein
  • rdh10 protein
  • SDR16C4 protein

Protein level used designations for RDH10

retinol dehydrogenase 10 , retinol dehydrogenase 10-B , retinol dehydrogenase 10 (all-trans) , retinol dehydrogenase 10-like , short chain dehydrogenase/reductase family 16C, member 4

GENE ID SPECIES
378722 Danio rerio
9223482 Arthroderma otae CBS 113480
100409203 Callithrix jacchus
157506 Homo sapiens
486998 Canis lupus familiaris
100127136 Sus scrofa
282852 Bos taurus
98711 Mus musculus
353252 Rattus norvegicus
420183 Gallus gallus
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