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Rh Family C Glycoprotein Proteins (RHCG)

Functions as an electroneutral and bidirectional ammonium transporter. Additionally we are shipping Rh Family C Glycoprotein Antibodies (82) and Rh Family C Glycoprotein Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RHCG 51458 Q9UBD6
Rat RHCG RHCG 293048 Q7TNN9
RHCG 56315 Q9QXP0
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Top Rh Family C Glycoprotein Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
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RHCG Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Rh Family C Glycoprotein (RHCG) Interaction Partners

Human Rh Family C Glycoprotein (RHCG) interaction partners

  1. The molecular mechanism of NH4(+) recruitment and NH3 transport by RHCG is described.

  2. Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion.

  3. RhAG (show RHAG Proteins), RhBG and RhCG-exhibit significant permeability to NH3 and show for the first time that RhBG and RhCG can conduct CO2.

  4. Amt (show AMT Proteins) and Rh proteins are not functionally equivalent and that permeation takes place according to two distinct mechanisms.

  5. X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport.

  6. major finding of this study is that RhCG protein is active as an NH(3) channel and that this function does not require any protein partner

  7. RhBG and RhCG facilitate ammonium movement across the plasma membrane; these results favor the hypothesis that these Rh glycoproteins, together with their homolog RhAG (show RHAG Proteins), constitute a family of NH3 channels in mammalian cells.

  8. RhCG expression enhanced the ammonium-induced initial alkalinization (related to NH3 influx)& secondary acidification (related to NH4+ influx). Sub-millimolar NH4+ concentrations induced inward currents in voltage-clamped RhCG-expressing cells.

  9. This study concludes that under normal conditions, RhCG is the major putative ammonia transporter expressed in the human kidney and RhBG is not expressed at detectable levels.

  10. Rhbg and Rhcg may contribute to bronchial epithelial cell ammonia metabolism and suggest that they do not contribute to pulmonary carbon dioxide transport.

Mouse (Murine) Rh Family C Glycoprotein (RHCG) interaction partners

  1. We characterized ammonia and ammonium (NH3/NH4 (+)) transport by the rhesus-associated (Rh) glycoproteins RhAG, Rhbg, and Rhcg expressed in Xenopus oocytes. We used ion-selective microelectrodes and two-electrode voltage clamp to measure changes in intracellular pH, surface pH, and whole cell currents induced by NH3/NH4 (+) and methyl amine/ammonium (MA/MA(+)).

  2. investigated the renal adaptive response of acid excretory pathways to high-protein diets containing normal or low amounts of acid-producing sulfur amino acids (SAA (show SAA1 Proteins)) and examined how this adaption requires the RhCG ammonia transporter

  3. Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion.

  4. Rhcg is critically important in the renal response to metabolic acidosis. in mice with intact Rhcg expression, metabolic acidosis does not induce maximal changes in PEPCK (show PEPCK Proteins), NHE-3 (show SLC9A3 Proteins), and GS expression despite the presence of persistent metabolic acidosis.

  5. hypokalemia increases collecting duct Rhcg expression, and this likely contributes to the hypokalemia-stimulated increase in urinary ammonia excretion, and its adaptive increases in phosphate-dependent glutaminase (show GLS2 Proteins) expression can compensate for the absence of collecting duct Rhcg.

  6. Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct

  7. Rhcg expression in intercalated cells is necessary for the normal renal response to metabolic acidosis, contributing to both basal and acidosis-stimulated ammonia excretion. Adaptations in Rhbg expression occur in response to acid-loading.

  8. Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney.

  9. RhBG and RhCG are present in a major site of ammonia secretion in the kidney, i.e., the CNT and CD, in agreement with their putative role in ammonium transport.

  10. RhCG immunoreactivity is present in bile duct epithelial cells, where it may contribute to ammonium secretion into bile fluid.

Rh Family C Glycoprotein (RHCG) Protein Profile

Protein Summary

Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.

Gene names and symbols associated with RHCG

  • Rh family, C glycoprotein (RHCG)
  • Rh type C glycoprotein (LOC445729)
  • Rh family, C glycoprotein (Rhcg)
  • Rhesus blood group-associated C glycoprotein (Rhcg)
  • BB065800 protein
  • C15orf6 protein
  • PDRC2 protein
  • RHGK protein
  • SLC42A3 protein

Protein level used designations for RHCG

ammonia transporter RhCG , ammonium transporter Rh type C , Rh type C glycoprotein , Rhesus blood group, C glycoprotein , rh family type C glycoprotein , rh glycoprotein kidney , rhesus blood group family type C glycoprotein , tumor-related protein DRC2 , Rhesus blood group-associated C glycoprotein , Rhesus type C glycoprotein , rh type C glycoprotein , rhesus-associated C glycoprotein

GENE ID SPECIES
100528009 Ovis aries
445729 Ciona intestinalis
51458 Homo sapiens
293048 Rattus norvegicus
479040 Canis lupus familiaris
733644 Sus scrofa
281456 Bos taurus
415490 Gallus gallus
100009494 Oryctolagus cuniculus
664731 Macaca mulatta
453638 Pan troglodytes
56315 Mus musculus
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