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Cooperates with PTBP1 to modulate regulated alternative splicing events. Additionally we are shipping Ribonucleoprotein, PTB-Binding 1 Antibodies (35) and many more products for this protein.
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RAVER1 specifically regulates MDA5 (show IFIH1 Proteins) activity, revealing a mechanism of differential regulation of MDA5 (show IFIH1 Proteins)- and RIG-I (show DDX58 Proteins)-mediated innate antiviral response.
These binding assays show that raver1 forms a ternary complex with metavinculin (show VCL Proteins) and vinculin (show VCL Proteins) mRNA.
Raver1 gene promoter region shares common features of ubiquitously expressed gene with the interacting splicing regulator PTB (show PTBP2 Proteins)
RAVER1 interactions with vinculin (show VCL Proteins) and RNA suggest a feed forward pathway in directing messenger RNA to focal adhesions.
PTB (show PTBP1 Proteins)-mediated splicing repression involves recruitment of raver1 as a potent splicing co-repressor.
In mice, raver1 might link gene expression with structural functions of muscle contractility during muscle differentiation.
raver1 may play an important role for the regulation of neuronal synaptic plasticity, possibly by controlling especially the late LTP (show SCP2 Proteins) via posttranscriptional mechanisms.
Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).
, ribonucleoprotein, PTB-binding 1
, protein raver-1
, ribonucleoprotein PTB-binding 1
, RAVER1 homolog