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Ribonucleotide Reductase M1 Proteins (RRM1)

RRM1 encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Additionally we are shipping Ribonucleotide Reductase M1 Antibodies (117) and Ribonucleotide Reductase M1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RRM1 6240 P23921
RRM1 20133 P07742
Rat RRM1 RRM1 685579  
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Top Ribonucleotide Reductase M1 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
Yeast Human His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RRM1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine)

More Proteins for Ribonucleotide Reductase M1 (RRM1) Interaction Partners

Human Ribonucleotide Reductase M1 (RRM1) interaction partners

  1. A significant association has been found between RRM1 rs12806698 (-269C>A) RRM1 genotype and the risk for developing non-small cell lung cancer.

  2. Results underline the relevance of microRNA-101-3p-driven regulation of RRM1 in pancreatic ductal carcinoma gemcitabine resistance.

  3. TUBB3 (show TUBB3 Proteins), TOP2A (show TOP2A Proteins), CYP19A1 (show CYP19A1 Proteins) and CYP2D6 (show CYP2D6 Proteins) gene expression, but not protein expression, was associated with patient survival.

  4. A possible predictive impact of ribonucleotide-reductase subunit-1 (RRM1) on vinorelbine efficacy in non-small cell lung cancer (NSCLC) has been previously reported.

  5. RRM1 expression was predictive and prognostic of clinical outcome in advanced UC treated with gemcitabine plus platinum combination chemotherapy

  6. RNA expression of deoxycytidine kinase (DCK (show DCK Proteins)), human equilibrative nucleoside transporter-1 (ENT1 (show SLC29A1 Proteins)) and ribonucleotide reductase M1 (RRM1) were significantly higher and cytidine deaminase (CDA (show CDA Proteins)) was significantly lower in ex vivo Ara (show FOXC1 Proteins)-C sensitive samples.

  7. Bmi1 (show BMI1 Proteins) and possibly RNF2 (show RNF2 Proteins) may be attractive biomarkers of gemcitabine resistance in the context of RRM1 expression.

  8. For RRM1 C37A-T524C genotype, sensitive group had higher proportion of high effective genotype than non-sensitive group (p=0.009).

  9. Adenoviral vector expressing short hairpin RNA targeting RRM1 exerts potent antitumor effects and increases sensitivity to gemcitabine.

  10. we propose that RRM1 protein can inhibit CRC invasion and metastasis at the advanced stage by regulating PTEN transactivation and its downstream pathways in addition to forming an RR holoenzyme for supporting cancer proliferation.

Mouse (Murine) Ribonucleotide Reductase M1 (RRM1) interaction partners

  1. This work reveals that binding of RRM1 to RRM2 (show RRM2 Proteins) is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.

  2. analysis of transgenic overexpression of ribonucleotide reductase Rrm1 and Rrm2 (show RRM2 Proteins) improves cardiac performance

  3. silencing RRM1 expression using siRNA could potentially be an effective strategy to overcome gemcitabine resistance.

  4. Tip60 (show KAT5 Proteins)-dependent recruitment of RNR plays an essential role in dNTP supply for DNA repair

  5. The hexamer form of murine ribonucleotide reductase (mRR) large catalytic subunit mR1 (show MR1 Proteins)(6) predominates over the dimer form mR1 (show MR1 Proteins)(2) in the cytoplasm of normal cells, where the great majority of mRR activity is located.

  6. overexpression of RRM1 in human and mouse lung cancer cell lines induced PTEN expression, reduced phosphorylation of focal adhesion kinase (FAK), suppressed migration, invasion, and metastasis formation, and increased survival in an animal model.

Ribonucleotide Reductase M1 (RRM1) Protein Profile

Protein Summary

This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.

Gene names and symbols associated with RRM1

  • ribonucleotide reductase M1 (RRM1)
  • Ribonucleoside diphosphate reductase large subunit (RnrL)
  • ribonucleotide reductase M1 (rrm1)
  • ribonucleotide reductase M1 (Rrm1)
  • ribonucleotide reductase M1 polypeptide (rrm1)
  • cb396 protein
  • cb838 protein
  • CG5371 protein
  • CHUNP6866 protein
  • Dmel\\CG5371 protein
  • DmRNR1 protein
  • l(2)k06709 protein
  • r1 protein
  • RIR1 protein
  • RNR1 protein
  • RnrM1 protein
  • RntL protein
  • RR1 protein
  • sb:cb548 protein
  • wu:fb39b07 protein
  • wu:fi14b02 protein
  • wu:fk95f07 protein
  • XRRM1 protein

Protein level used designations for RRM1

ribonucleoside diphosphate reductase large subunit , CG5371-PA , RnrL-PA , ribonucleoside diphosphate reductase M1 subunit , ribonucleoside-diphosphate reductase large subunit , ribonucleoside-diphosphate reductase M1 chain , ribonucleotide reductase M1 polypeptide , ribonucleotide reductase M1 , ribonucleoside-diphosphate reductase large subunit-like , ribonucleoside-diphosphate reductase subunit M1 , ribonucleotide reductase, R1 subunit , ribonucleotide reductase large subunit , ribonucleotide reductase protein r1 class I

GENE ID SPECIES
100053126 Equus caballus
34392 Drosophila melanogaster
450974 Pan troglodytes
717990 Macaca mulatta
100472317 Ailuropoda melanoleuca
100562780 Anolis carolinensis
100599741 Nomascus leucogenys
399431 Xenopus laevis
419081 Gallus gallus
6240 Homo sapiens
476823 Canis lupus familiaris
505537 Bos taurus
20133 Mus musculus
685579 Rattus norvegicus
100525117 Sus scrofa
100172956 Pongo abelii
30740 Danio rerio
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