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RRM2 encodes one of two non-identical subunits for ribonucleotide reductase. Additionally we are shipping RRM2 Proteins (15) and RRM2 Kits (6) and many more products for this protein.
Showing 10 out of 71 products:
Human Monoclonal RRM2 Primary Antibody for IF, IHC (p) - ABIN562744
Tang, Deng, Wang, Dai, Wang, Jiang, Li, Li, Sheng, Wu, Li, Zeng et al.: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in ... in Molecular & cellular proteomics : MCP 2007
Show all 4 references for ABIN562744
Human Polyclonal RRM2 Primary Antibody for EIA, WB - ABIN453352
Liu, Xue, Yen: Redox property of ribonucleotide reductase small subunit M2 and p53R2. in Methods in molecular biology (Clifton, N.J.) 2008
Show all 2 references for ABIN453352
Cow (Bovine) Polyclonal RRM2 Primary Antibody for WB - ABIN2782440
Souglakos, Boukovinas, Taron, Mendez, Mavroudis, Tripaki, Hatzidaki, Koutsopoulos, Stathopoulos, Georgoulias, Rosell: Ribonucleotide reductase subunits M1 and M2 mRNA expression levels and clinical outcome of lung adenocarcinoma patients treated with docetaxel/gemcitabine. in British journal of cancer 2008
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Human Polyclonal RRM2 Primary Antibody for IF, WB - ABIN2452118
Takada, Shibata, Hiraoka, Masuda: Identification of ribonucleotide reductase protein R1 as an activator of microtubule nucleation in Xenopus egg mitotic extracts. in Molecular biology of the cell 2000
A significant association has been found between RRM2 rs6759180 (located in the 5'UTR (show UTS2R Antibodies), 10126436G>A) and the risk for developing non-small cell lung cancer.
Data show that ribonucleotide reductase M2 (RRM2) is associated with increased nuclear factor kappa B (NF-kappaB (show NFKB1 Antibodies)) activity.
our findings establish a signaling role for RRM2 in gastric cancer cells and identify that the RRM2/AKT (show AKT1 Antibodies)/NF-kappaB (show NFKB1 Antibodies) signaling pathway is essential for tumor invasiveness in gastric cancer cells
HBV exploits the Chk1 (show CHEK1 Antibodies)-E2F1 (show E2F1 Antibodies) axis of the DNA damage response pathway to induce R2 expression in a cell cycle-independent manner.
High expression level of RRM2 might be negative prognostic factor for resected NSCLC patients.
We suggest that MNNG-stimulated ATR (show ANTXR1 Antibodies)/CHK1 (show CHEK1 Antibodies) signaling stabilizes E2F3 by S124 phosphorylation, and then E2F3 together with NFY co-transactivate RRM2 expression for DNA repair.
In non-small cell lung cancer, RRM2 expression was predictive of disease-specific survival in women, non-smokers and former smokers. Higher expression was associated with worse survival. This was not the case for men, and current or recently quit smokers.
These results suggested that RRM2 supported the growth of human OSCC cells and that targeting of RRM2, e.g., via GEM (show GEM Antibodies) treatment, may be a promising therapeutic strategy for OSCC.
Understanding the role of E2F1 (show E2F1 Antibodies) in activating RRM2 transcription will help to explain the relationship between E2F1 (show E2F1 Antibodies) and RRM2 in colorectal cancer
R2 and p53R2 (show RRM2B Antibodies) small subunits are subject to caspase (show CASP3 Antibodies)-dependent degradation
This work reveals that binding of RRM1 (show RRM1 Antibodies) to RRM2 is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.
mice carrying extra alleles of the RNR (show REN1 Antibodies) regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR (show REN1 Antibodies) activity and reduced chromosomal breakage at fragile sites
analysis of transgenic overexpression of ribonucleotide reductase Rrm1 (show RRM1 Antibodies) and Rrm2 improves cardiac performance
Cinobufotalin significantly inhibits the growth of the xenografts of endometrial carcinoma Ishikawa in nude mice by inhibiting RRM2 expression.
Data suggest that RRM2 may be an important effector of progesterone signaling to induce cell proliferation and decidualization in uterus.
illegitimate recombination initiated by c-Myc (show MYC Antibodies)
Adrenergic stimulation of brown adipocytes elevates ribonucleotide reductase subunit R2 in the proliferative stage of adipocyte development; mediating pathways include cAMP/PKA cascades, Src (show SRC Antibodies) and Erk (show EPHB2 Antibodies) Map Kinases.
S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F (show E2F1 Antibodies)-binding site and an upstream promoter activating region
Chk1 is required for DNA replication at least through regulating RNR2 gene transcription.
results indicate that the affinity of the RNR (show REN1 Antibodies) R2 proteins for binding metals is determined by the nature of one specific residue in the vicinity of the dimetal site, namely the one that carries the tyrosyl radical in class Ia and Ib R2 proteins
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
ribonucleotide reductase M2 polypeptide
, ribonucleoside-diphosphate reductase subunit M2
, ribonucleotide reductase small chain
, ribonucleotide reductase small subunit
, ribonucleoside-diphosphate reductase M2 chain
, Ribonucleotide reductase 2
, reductase M2 polypeptide variant 1
, reductase M2 polypeptide variant 2
, reductase M2 polypeptide variant 3a
, reductase M2 polypeptide variant 3b
, reductase M2 polypeptide variant 3c
, reductase M2 polypeptide variant 3d
, ribonucleotide reductase protein r2 class I