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RPN2 encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. Additionally we are shipping Ribophorin II Antibodies (53) and Ribophorin II Kits (12) and many more products for this protein.
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Human Ribophorin II Protein expressed in Escherichia coli (E. coli) - ABIN1098507
Skarnes, Rosen, West, Koutsourakis, Bushell, Iyer, Mujica, Thomas, Harrow, Cox, Jackson, Severin, Biggs, Fu, Nefedov, de Jong, Stewart, Bradley: A conditional knockout resource for the genome-wide study of mouse gene function. in Nature 2011
Show all 2 references for ABIN1098507
Data suggest that RPN2 (show PSMD1 Proteins) is involved in the regulation of lethal cancer phenotypes and represents a promising new target for RNAi-based medicine against non-small cell lung cancer.
Of the total, the deregulation of several genes (CDK1 (show CDK1 Proteins), CDK2 (show CDK2 Proteins), CDK4 (show CDK4 Proteins), MCM2 (show MCM2 Proteins), MCM3 (show MCM3 Proteins), MCM4 (show MCM4 Proteins), EIF3a (show EIF6 Proteins) and RPN2 (show PSMD1 Proteins)) were potentially associated with disease development and progression.
these results indicated that high glycosylation of CD63 (show CD63 Proteins) by RPN2 (show PSMD1 Proteins) is implicated in clinical outcomes in breast cancer patients
Furthermore, our study reveals that high expression of RPN2 (show PSMD1 Proteins) and concomitant accumulation of mtp53 were associated with cancer tissues in a small cohort of metastatic breast cancer patients.
Rpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding.
RPN2 (show PSMD1 Proteins) gene confers docetaxel resistance in breast cancer.
S-glutathionylation of Rpn2 (show PSMD1 Proteins) is a contributory mechanism for H2O2-induced inhibition of 26 S proteasomal function
Data show that the decay of metabolically labeled p53 (show TP53 Proteins) follows biphasic kinetics, while 20 S proteasome executes the first phase by default, and the second phase requires the 26 S proteasome.
S-glutathionylation of Rpn2 is a contributory mechanism for H2O2-induced inhibition of 26 S proteasomal function
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
, ribophorin ii
, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
, dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
, dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like
, oligosaccharyltransferase complex subunit (non-catalytic)
, ribophorin 2