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The protein encoded by RNF121 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Additionally we are shipping RNF121 Proteins (3) and many more products for this protein.
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Cow (Bovine) Polyclonal RNF121 Primary Antibody for WB - ABIN2781291
Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004
Show all 2 references for ABIN2781291
findings identify RNF-121 as an ER-anchored ubiquitin ligase that plays a specific role in the ERAD pathway by linking it to the regulation of the cell adhesion integrin receptors through PAT-3, an RNF-121 substrate.
Over-expression of RNF121 promoted ubiquitination of VEGFR-2 (show KDR Antibodies), inhibited its maturation . RNF121 knockdown in primary endothelial cells reduced VEGFR-2 (show KDR Antibodies) ubiquitination and increased its cell surface level.
These results unveil an unexpected role of Golgi Apparatus and reveal RNF121 as a new player involved in the signaling leading to NF-kappaB (show NFKB1 Antibodies) activation.
This is the first study to demonstrate that RNF121 is a novel regulator of apoptosis and provides a new potential target for cancer therapy
these results indicate that RNF121 participates in the quality control of NaV channels during their synthesis and subsequent transport to the membrane.
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products.
RING finger protein 121