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The protein encoded by RNF135 contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Additionally we are shipping Ring Finger Protein 135 Antibodies (46) and many more products for this protein.
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findings demonstrate the biological effects of RNF135 in glioblastoma cell proliferation, migration and cell cycle, and its role in the progression of glioblastoma may be associated with the ERK (show EPHB2 Proteins) signal transduction pathway.
Data showed that the presence of the RNF135 K115 variant in the genotype of patients with autism was statistically significant.
Riplet-mediated K63-linked polyubiquitination released RIG-I (show DDX58 Proteins) RD autorepression, which allowed the access of positive factors to the RIG-I (show DDX58 Proteins) protein.
REUL is an E3 ubiquitin ligase (show MUL1 Proteins) of RIG-I (show DDX58 Proteins) and specifically stimulates RIG-I (show DDX58 Proteins)-mediated innate antiviral activity
These data identify RNF135 as causative of a new overgrowth syndrome and demonstrate that RNF135 haploinsufficiency contributes to the phenotype of NF1 (show NF1 Proteins) microdeletion cases.
identify an alternative factor, Riplet/RNF135, that promotes RIG-I (show DDX58 Proteins) activation independent of TRIM25 (show TRIM25 Proteins)
RNF135 mutations are not present in patients with Sotos syndrome-like features.
Riplet is essential for regulating RIG-I (show DDX58 Proteins)-mediated innate immune response against RNA virus infection in vivo.
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
E3 ubiquitin-protein ligase RNF135
, RIG-I E3 ubiquitin ligase
, U 2-3-0