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The protein encoded by RNF135 contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Additionally we are shipping Ring Finger Protein 135 Antibodies (43) and many more products for this protein.
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Data showed that the presence of the RNF135 K115 variant in the genotype of patients with autism was statistically significant.
Riplet-mediated K63-linked polyubiquitination released RIG-I (show DDX58 Proteins) RD autorepression, which allowed the access of positive factors to the RIG-I (show DDX58 Proteins) protein.
REUL is an E3 ubiquitin ligase (show MUL1 Proteins) of RIG-I (show DDX58 Proteins) and specifically stimulates RIG-I (show DDX58 Proteins)-mediated innate antiviral activity
These data identify RNF135 as causative of a new overgrowth syndrome and demonstrate that RNF135 haploinsufficiency contributes to the phenotype of NF1 (show NF1 Proteins) microdeletion cases.
identify an alternative factor, Riplet/RNF135, that promotes RIG-I (show DDX58 Proteins) activation independent of TRIM25 (show TRIM25 Proteins)
RNF135 mutations are not present in patients with Sotos syndrome-like features.
Riplet is essential for regulating RIG-I (show DDX58 Proteins)-mediated innate immune response against RNA virus infection in vivo.
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
E3 ubiquitin-protein ligase RNF135
, RIG-I E3 ubiquitin ligase
, U 2-3-0