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E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Additionally we are shipping RNF146 Proteins (11) and many more products for this protein.
Showing 10 out of 26 products:
Human Polyclonal RNF146 Primary Antibody for WB - ABIN2774795
von Rotz, Kins, Hipfel, von der Kammer, Nitsch: The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease. in The European journal of neuroscience 2005
the maintenance of unliganded RNF146 in an inactive state may serve to maintain the stability of the RNF146-TNKS (show TNKS Antibodies) complex, which in turn regulates the homeostasis of PARylation-dependent ubiquitination activity in the cell
RNF146 regulated the development and progression of NSCLC
Iduna is a Poly(ADP-ribose)-dependent ubiquitin E3 ligase.
RNF146/Iduna has been found to be implicated in neurodegenerative disease and cancer development. [Review]
the RNF146 WWE domain recognizes poly(ADP-ribose) (PAR) by interacting with iso-ADP-ribose (iso-ADPR), the smallest internal PAR structural unit containing the characteristic ribose-ribose glycosidic bond formed during poly(ADP-ribosyl)ation.
RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt (show WNT2 Antibodies) signaling that operates with tankyrase to maintain low steady-state levels of Axin (show AXIN1 Antibodies) proteins
Dactylidin may function early in the progression of Alzheimer's disease.
Mutations in the coding regions of the RNF146 and ECHDC1 (show ECHDC1 Antibodies) genes do not contribute to the burden of inherited predisposition of breast cancer in Ashkenazi high risk women.
Modulation of PARP-1 (show PARP1 Antibodies)-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes
Iduna acts as a potential antioxidant by improving mitochondrial function and inhibiting oxidative stress-induced parthanatos, and these protective effects are dependent on the involvement of ubiquitin-proteasome system.
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP- ribosylated proteins (By similarity).
, E3 ubiquitin-protein ligase RNF146
, E3 ubiquitin-protein ligase RNF146-B
, RING finger protein 146-B
, E3 ubiquitin-protein ligase rnf146