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Ring Finger Protein 146 Proteins (RNF146)

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Additionally we are shipping RNF146 Antibodies (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RNF146 81847 Q9NTX7
RNF146 68031 Q9CZW6
Rat RNF146 RNF146 308051 Q5XIK5
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Top RNF146 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag   0.5 mL Log in to see 1 to 2 Days
$330.00
Details
HOST_Escherichia coli (E. coli) Human GST tag   0.5 mL Log in to see 1 to 2 Days
$110.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,839.83
Details
Yeast REACT_Atlantic Salmon His tag   1 mg Log in to see 56 to 66 Days
$2,948.00
Details
Yeast REACT_Panda His tag   1 mg Log in to see 56 to 66 Days
$2,979.17
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,982.83
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,995.67
Details

RNF146 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Top referenced RNF146 Proteins

  1. Human RNF146 Protein expressed in Escherichia coli (E. coli) - ABIN1741734 : Kang, Lee, Shin, Andrabi, Chi, Gagné, Lee, Ko, Lee, Poirier, Dawson, Dawson: Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 7 references for ABIN1741734

  2. Human RNF146 Protein expressed in Escherichia coli (E. coli) - ABIN1741735 : Zhang, Liu, Mickanin, Feng, Charlat, Michaud, Schirle, Shi, Hild, Bauer, Myer, Finan, Porter, Huang, Cong: RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. in Nature cell biology 2011 (PubMed)
    Show all 7 references for ABIN1741735

More Proteins for Ring Finger Protein 146 (RNF146) Interaction Partners

Human Ring Finger Protein 146 (RNF146) interaction partners

  1. the maintenance of unliganded RNF146 in an inactive state may serve to maintain the stability of the RNF146-TNKS (show TNKS Proteins) complex, which in turn regulates the homeostasis of PARylation-dependent ubiquitination activity in the cell

  2. RNF146 regulated the development and progression of NSCLC

  3. Iduna is a Poly(ADP-ribose)-dependent ubiquitin E3 ligase.

  4. RNF146/Iduna has been found to be implicated in neurodegenerative disease and cancer development. [Review]

  5. the RNF146 WWE domain recognizes poly(ADP-ribose) (PAR) by interacting with iso-ADP-ribose (iso-ADPR), the smallest internal PAR structural unit containing the characteristic ribose-ribose glycosidic bond formed during poly(ADP-ribosyl)ation.

  6. RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt (show WNT2 Proteins) signaling that operates with tankyrase to maintain low steady-state levels of Axin (show AXIN1 Proteins) proteins

  7. Dactylidin may function early in the progression of Alzheimer's disease.

  8. Mutations in the coding regions of the RNF146 and ECHDC1 (show ECHDC1 Proteins) genes do not contribute to the burden of inherited predisposition of breast cancer in Ashkenazi high risk women.

Mouse (Murine) Ring Finger Protein 146 (RNF146) interaction partners

  1. Modulation of PARP-1 (show PARP1 Proteins)-mediated oxidative cell injury by ring finger protein 146 (RNF146) in cardiac myocytes

  2. Iduna acts as a potential antioxidant by improving mitochondrial function and inhibiting oxidative stress-induced parthanatos, and these protective effects are dependent on the involvement of ubiquitin-proteasome system.

RNF146 Protein Profile

Protein Summary

E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP- ribosylated proteins (By similarity).

Gene names and symbols associated with RNF146

  • ring finger protein 146 (RNF146)
  • ring finger protein 146 (Rnf146)
  • ring finger protein 146 (RNF146B)
  • RING finger protein 146 (rn146)
  • ring finger protein 146 (rnf146)
  • 2610509H23Rik protein
  • dactylidin protein
  • dJ351K20.1 protein
  • Iduna protein
  • rnf146 protein
  • RP3-351K20.1 protein
  • wu:fi29e08 protein
  • zgc:55909 protein

Protein level used designations for RNF146

2610509H23Rik , E3 ubiquitin-protein ligase RNF146 , dactylidin , iduna , E3 ubiquitin-protein ligase RNF146-B , RING finger protein 146-B , E3 ubiquitin-protein ligase rnf146

GENE ID SPECIES
100067400 Equus caballus
81847 Homo sapiens
68031 Mus musculus
308051 Rattus norvegicus
425313 Gallus gallus
476288 Canis lupus familiaris
100512692 Sus scrofa
767901 Bos taurus
100380617 Salmo salar
443895 Xenopus laevis
334065 Danio rerio
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