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RNF170 encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. Additionally we are shipping Ring Finger Protein 170 Proteins (6) and many more products for this protein.
Showing 10 out of 38 products:
Chicken Polyclonal RNF170 Primary Antibody for WB - ABIN2774794
Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004
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Dog (Canine) Polyclonal RNF170 Primary Antibody for WB - ABIN2774793
Gunnarsdóttir, Li, Bauchet, Finstermeier, Stoneking: High-throughput sequencing of complete human mtDNA genomes from the Philippines. in Genome research 2011
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aberrant ubiquitination of substrates, or cellular adaptation to chronically reduced RNF170 levels likely accounts for the autosomal dominant sensory ataxia (show USP14 Antibodies)-associated Ca2 (show CA2 Antibodies)+ signaling deficit
RNF170 plays an essential role in IP(3) receptor processing via the ubiquitin-proteasome pathway.
Together these results suggest that the mutation in RNF170 is causal for the sensory ataxia (show USP14 Antibodies)
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene.
E3 ubiquitin-protein ligase RNF170
, putative LAG1-interacting protein
, RING finger protein 170