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The protein encoded by RNF19A contains two RING-finger motifs and an IBR (in between RING fingers) motif. Additionally we are shipping Ring Finger Protein 19A Proteins (3) and many more products for this protein.
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Cow (Bovine) Polyclonal RNF19A Primary Antibody for ELISA - ABIN268634
Niwa, Ishigaki, Doyu, Suzuki, Tanaka, Sobue: A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. in Biochemical and biophysical research communications 2001
Cow (Bovine) Polyclonal RNF19A Primary Antibody for WB - ABIN2774733
Ishigaki, Niwa, Yamada, Takahashi, Ito, Sone, Doyu, Urano, Sobue: Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity. in Neurobiology of disease 2007
porcine RNF19 gene maps to chromosome 4 (4p11-p12 (show SPRN Antibodies)), consistent with the currently known conservation of genome organization between human and pig.
These results suggest that Dorfin may regulate adult neurogenesis, synaptic plasticity, and contextual fear memory.
In addition to causing a decrease in the amount of mutant SOD1 (show SOD1 Antibodies) protein in the spinal cord, Dorfin overexpression ameliorated neurological phenotypes and motor neuron degeneration (show CLN8 Antibodies) in a mouse model of amyotrophic lateral sclerosis.
Dorfin ubiquitylated mutant SOD1 (show SOD1 Antibodies) by recognizing the Cys (show DNAJC5 Antibodies)(6)- and Cys (show DNAJC5 Antibodies)(111)-disulfide cross-linked form and targeted it for proteasomal degradation
A more than 2-fold higher level of RNF19A mRNA in the blood of patients with prostate cancer than in healthy controls makes it an early diagnosis marker for this disease.
Dorfin has a role in ubiquitylating mutant SOD1 (show SOD1 Antibodies) proteins and targeting them for proteasomal degradation
results suggest that synphilin-1 (show SNCAIP Antibodies) has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 (show SNCAIP Antibodies)
These results suggest that Dorfin plays a crucial role in the formation of ubiquitylated inclusions of alpha-synucleinopathy and amyotrophic lateral sclerosis.
Reducing the accumulation of mutant superoxide dismutase 1 (show SOD1 Antibodies) [SOD1 (show SOD1 Antibodies)] in the mitochondria may be a new therapeutic strategy for mutant SOD1 (show SOD1 Antibodies)-associated familial amyotrophic lateral sclerosis, and Dorfin may play a significant role in this
Valosin-containing protein (show vcp Antibodies) functionally regulates Dorfin through direct interaction
Dorfin-CHIP(L) rescued neuronal cells from mutant SOD1 (show SOD1 Antibodies)-associated toxicity and reduced the aggresome formation induced by mutant SOD1 (show SOD1 Antibodies) more effectively than did Dorfin(WT).
Findings suggest that RNF19 has acquired a new promoter and alternative exons via continuous retrotransposition.
The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies, a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein binds and ubiquitylates synphilin 1 (SNCAIP) which is an interacting protein of alpha synuclein in neurons and a major component of Lewy bodies. Alternative splicing results in multiple transcript variants encoding the same protein.
E3 ubiquitin-protein ligase RNF19A
, RING finger protein 19A
, double ring-finger protein
, UBCM4-interacting protein 117
, XY body protein
, gametogenesis-expressed protein GEG-154
, ring finger protein (C3HC4 type) 19
, ubiquitin conjugating enzyme 7 interacting protein 2
, protein p38 interacting with transcription factor Sp1
, ring-IBR-ring domain containing protein Dorfin
, ring finger protein 19