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anti-Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) Antibodies

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. Additionally we are shipping RFWD2 Proteins (5) and RFWD2 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RFWD2 26374 Q9R1A8
RFWD2 689375  
RFWD2 64326 Q8NHY2
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Top anti-RFWD2 Antibodies at antibodies-online.com

Showing 10 out of 77 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from K562 cells treated with UV 15', using RFWD2 (Phospho-Ser387) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from LOVO cells, using RFWD2 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB RFWD2 Antibody (C-term) (ABIN1881747) western blot analysis in SK-BR-3 cell line lysates (35 µg/lane). This demonstrates the RFWD2 antibody detected the RFWD2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, WB COP1 Antibody (N-term) (ABIN655275) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the COP1 antibody detected the COP1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to RFWD2 on NIH/3T3 cell (antibody concentration 10 µg/mL). RFWD2 monoclonal antibody (M01), clone 1E4 Western Blot analysis of RFWD2 expression in NIH/3T3. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB Mouse Thymus; WB Suggested Anti-Rfwd2 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse Thymus; Rfwd2 antibody - middle region in Mouse Thymus cells using Western Blot 50 μg Log in to see 6 to 8 Days
$401.50
Details

RFWD2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Rat (Rattus)


Human , ,
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Top referenced anti-RFWD2 Antibodies

  1. Human Polyclonal RFWD2 Primary Antibody for WB - ABIN1881747 : Li, Ohshiro, Reddy, Pakala, Lee, Zhang, Rayala, Kumar: E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. in Proceedings of the National Academy of Sciences of the United States of America 2009 (PubMed)
    Show all 3 references for ABIN1881747

  2. Human Polyclonal RFWD2 Primary Antibody for ELISA, WB - ABIN1532168 : Wertz, ORourke, Zhang, Dornan, Arnott, Deshaies, Dixit: Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. in Science (New York, N.Y.) 2004 (PubMed)

More Antibodies against RFWD2 Interaction Partners

Arabidopsis thaliana Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. Data indicate a coordinated regulation of Arabidopsis proteins SHW1, COP1, and HY5 in seedling development.

  2. The COP1 role in CONSTANS protein degradation during photoperiodic flowering

  3. CSU2 interacts with COP1 via the coiled-coil domain association. CSU2 negatively regulates COP1 E3 ubiquitin ligase (show MUL1 Antibodies) activity. [COP1]

  4. propose that light perceived by phytochromes causes a switch in the ubiquitination activity of COP1/SPA2 from ubiquitinating downstream substrates to ubiquitinating SPA2, which subsequently causes a repression of COP1/SPA2 function

  5. CUL4(COP1-SPA) E3 ubiquitin ligase is necessary for the light-induced degradation of PIF1 in Arabidopsis.

  6. genetic analyses with transgenes expressing a genomic pmARI12:ARI12-GFP construct confirm the epistatic interaction between COP1 and ARI12 in growth responses to high fluence rate UV-B.

  7. Interaction of phyB with SPA1 promotes COP1-SPA1 dissociation and photomorphogenic development.

  8. AN3 may act with other proteins that bind to COP1 promoter to promote anthocyanin accumulation and inhibit light-induced root elongation.

  9. Two distinct domains of the UVR8 photoreceptor interact with COP1 to initiate UV-B signaling in Arabidopsis

  10. The Transcriptional Regulator BBX19 Promotes Hypocotyl Growth by Facilitating COP1-Mediated EARLY FLOWERING3 Degradation in Arabidopsis

Mouse (Murine) Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. Study shows that post-translational regulation of the transcription factors ETV1 (show ETV1 Antibodies), ETV4 (show ETV4 Antibodies), and ETV5 (show ETV5 Antibodies) by the ubiquitin ligase (show RNF123 Antibodies) COP1 (also called RFWD2) in beta cells is critical for insulin (show INS Antibodies) secretion. Mice lacking COP1 in beta cells developed diabetes due to insulin (show INS Antibodies) granule docking defects that were fully rescued by genetic deletion of Etv1 (show ETV1 Antibodies), Etv4 (show ETV4 Antibodies), and Etv5 (show ETV5 Antibodies).

  2. These results indicate that COP1 and Trib1 (show TRIB1 Antibodies) act as an oncoprotein complex functioning upstream of C/EBPalpha (show CEBPA Antibodies), and its ligase activity is crucial for leukemogenesis.

  3. COP1 physically interacted with PTP1B (show PTPN1 Antibodies) and suppressed PTP1B (show PTPN1 Antibodies) phosphatase activity as well as the association of PTP1B (show PTPN1 Antibodies) with IRbeta.

  4. Modulation of fatty acid synthase (show FASN Antibodies) degradation by concerted action of p38 MAP kinase (show MAPK14 Antibodies), E3 ligase COP1, and SH2 (show MYO15 Antibodies)-tyrosine phosphatase Shp2 (show PTPN11 Antibodies).

  5. the ubiquitin ligase (show RNF123 Antibodies) COP1 (also known as RFWD2) is a tumour suppressor that negatively regulates ETV1 (show ETV1 Antibodies), ETV4 (show ETV4 Antibodies) and ETV5 (show ETV5 Antibodies); ETV1 (show ETV1 Antibodies), which is mutated in prostate cancer more often, was degraded after being ubiquitinated by COP1

  6. Cop1 is a tumor suppressor that functions, at least in part, by antagonizing c-Jun (show JUN Antibodies) oncogenic activity.

  7. Rfwd2 is associated with acute lung injury

  8. description of a pathway in which Tribbles 3 (TRB3 (show TRIB3 Antibodies)) stimulates lipolysis by triggering the degradation of acetyl-coenzyme A carboxylase (ACC (show ACACA Antibodies)) in adipose tissue; TRB3 (show TRIB3 Antibodies) promoted ACC (show ACACA Antibodies) ubiquitination through an association with the E3 ubiquitin ligase (show MUL1 Antibodies) COP1

  9. Disruption of the COP1-mediated proteolysis by ionizing radiation leads to MTA1 (show MTA1 Antibodies) stabilization.

Human Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) interaction partners

  1. the present study revealed that COP1 (show CARD16 Antibodies) plays an important role in CLL cell proliferation and tumorigenicity, and may be a useful indicator of the chronic lymphocytic leukemia processes.

  2. COP1 (show CARD16 Antibodies) directly interacts with p27 (show PAK2 Antibodies) through a VP motif on p27 (show PAK2 Antibodies) and functions as an E3 ligase of p27 (show PAK2 Antibodies) to accelerate the ubiquitin-mediated degradation of p27 (show PAK2 Antibodies). COP1 (show CARD16 Antibodies)-p27 (show PAK2 Antibodies) axis deregulation is involved in tumorigenesis.

  3. COP1 (show CARD16 Antibodies) overexpression leads to the cytoplasmic distribution of p27 (show PAK2 Antibodies), thereby accelerating p27 (show PAK2 Antibodies) degradation.

  4. COP1 (show CARD16 Antibodies) negatively regulates ETV1 (show ETV1 Antibodies) in patients with triple-negative breast cancer.

  5. TRIB2 (show TRIB2 Antibodies) associated-ubiquitin E3 ligases beta-transducin repeat-containing E3 ubiquitin protein ligase (beta-TrCP (show BTRC Antibodies)), COP1 (show CARD16 Antibodies) and Smad ubiquitination regulatory factor 1 (Smurf1 (show SMURF1 Antibodies)) reduced TCF4 (show TCF4 Antibodies)/beta-Catenin (show CTNNB1 Antibodies) expression, and these effects could be enhanced by TRIB2 (show TRIB2 Antibodies).

  6. Phosphorylation of the ETS1 (show ETS1 Antibodies) and ETS2 (show ETS2 Antibodies) transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 (show CARD16 Antibodies) tumor suppressor protein (show TP53 Antibodies).

  7. while the role of COP1 (show CARD16 Antibodies) in malignancies is controversial, our current data support that COP1 (show CARD16 Antibodies) acts as a tumor suppressor in gastric cancer.

  8. co-expressing COP1 (show CARD16 Antibodies) and active GSK3beta (show GSK3b Antibodies) blocked in vitro cell growth/migration and in vivo metastasis of invasive breast cancer cells.

  9. COP1 (show CARD16 Antibodies) physically interacted with PTP1B (show PTPN1 Antibodies) and suppressed PTP1B (show PTPN1 Antibodies) phosphatase activity as well as the association of PTP1B (show PTPN1 Antibodies) with IRbeta.

  10. Modulation of fatty acid synthase (show FASN Antibodies) degradation by concerted action of p38 MAP kinase (show MAPK14 Antibodies), E3 ligase COP1 (show CARD16 Antibodies), and SH2-tyrosine phosphatase Shp2 (show PTPN11 Antibodies).

RFWD2 Antigen Profile

Protein Summary

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1 (By similarity).

Gene names and symbols associated with RFWD2

  • E3 ubiquitin-protein ligase COP1 (COP1) antibody
  • ring finger and WD repeat domain 2 (Rfwd2) antibody
  • ring finger and WD repeat domain 2-like 1 (Rfwd2l1) antibody
  • ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (RFWD2) antibody
  • AI316802 antibody
  • ARABIDOPSIS THALIANA CONSTITUTIVE PHOTOMORPHOGENIC 1 antibody
  • ATCOP1 antibody
  • C80879 antibody
  • CONSTITUTIVE PHOTOMORPHOGENIC 1 antibody
  • COP1 antibody
  • DEETIOLATED MUTANT 340 antibody
  • DET340 antibody
  • EMB168 antibody
  • EMBRYO DEFECTIVE 168 antibody
  • FUS1 antibody
  • FUSCA 1 antibody
  • Rfwd2 antibody
  • RNF200 antibody
  • T21L14.11 antibody
  • T21L14_11 antibody

Protein level used designations for RFWD2

E3 ubiquitin-protein ligase RFWD2 , RING finger and WD repeat domain protein 2 , constitutive photomorphogenesis protein 1 homolog , constitutive photomorphogenic protein 1 , mCOP1 , ring finger and WD repeat domain 2-like 1 , ring finger and WD repeat domain 2 , RING finger protein 200 , constitutive photomorphogenic protein (COP1) , hCOP1 , putative ubiquitin ligase COP1

GENE ID SPECIES
817857 Arabidopsis thaliana
26374 Mus musculus
689375 Rattus norvegicus
64326 Homo sapiens
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