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Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) Proteins (RUNX1T1)

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Additionally we are shipping RUNX1T1 Antibodies (36) and RUNX1T1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
Rat RUNX1T1 RUNX1T1 362489  
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Top RUNX1T1 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RUNX1T1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaction Partners

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Exon splicing patterns in the human RUNX1 (show RUNX1 Proteins)-RUNX1T1 fusion gene present in acute myeloid leukemia (show BCL11A Proteins) patients have been decoded.

  2. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1 (show RUNX1 Proteins)-ETO/RUNX1 (show RUNX1 Proteins)-RUNX1T1 is facilitated by interaction with the chaperonin (show HSPD1 Proteins) TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70 (show HSP70 Proteins)).

  3. AML1/ETO transactivates gene expression through recruiting AP-1 to the AML1/ETO-AML1 complex.

  4. A substantial fraction of AML1 (show RUNX1 Proteins)-ETO/p300 (show EP300 Proteins) co-localization occurs near TSSs in promoter regions associated with transcriptionally active loci.

  5. minimal residual disease determined by RUNX1/RUNX1T1 transcript levels could identify allogeneic hematopoietic stem cell transplantation t(8;21) (q22;q22) acute myeloid leukemia patients who are at high risk for relapse, together with c-KIT mutations

  6. identify a high-frequency mutation in t(8;21)/RUNX1 (show RUNX1 Proteins)-RUNX1T1 acute myekoid leukemia (AML (show RUNX1 Proteins)) and identify the need for future studies to investigate the clinical and biological relevance of ASXL2 mutations in this unique subset of AML (show RUNX1 Proteins)

  7. RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors are rescued by activating c-Kit mutations

  8. In t(8;21) acute myelogenous leukemia (AML), the acquisition of AML1/ETO is not sufficient, and the subsequent upregulation of AML1/ETO and the additional c-KIT mutant signaling are critical steps for transformation into leukemic stem cells.

  9. Our data shows that upregulated of the RUNX1 (show RUNX1 Proteins)-RUNX1T1 gene set maybe an important factor contributing to the etiology of ccRCC.

  10. RUNX1T1 gene may participate in t(8;21)(q22;q22)-dependent leukemic transformation due to its multiple interactions in cell regulatory network particularly through synergistic or antagonistic effects in relation to activity of RUNX1 (show RUNX1 Proteins)-RUNX1T1 fusion gene.

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Data show that RUNX1 (show RUNX1 Proteins)-ETO;c-Kit(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) in a fraction (51%) of reconstituted mice.

  2. Self-renewal induced by AML1 (show RUNX1 Proteins)/ETO in primary murine progenitors was inhibited when Aes (show AES Proteins) was decreased or absent.

  3. AML1 (show RUNX1 Proteins)-ETO synergizes with an ICSBP (show IRF8 Proteins) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  4. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (show CEBPB Proteins) and a novel regulator of early adipogenesis

  5. the loss of the molecular events of AML1 (show RUNX1 Proteins)-ETO C-terminal NCoR (show NCOR1 Proteins)/SMRT-interacting domain transforms AML1 (show RUNX1 Proteins)-ETO into a potent leukemogenic protein

  6. p15(Ink4b (show CDKN2B Proteins)) loss must be accompanied by additional oncogenic changes for RUNX1 (show RUNX1 Proteins)-ETO-associated AML (show RUNX1 Proteins) to develop

  7. AML1 DNA-binding domain and the ETO NHR2-dimerization domain, but not the ETO NHR1 domain, are critical for the induction of acute myeloid leukemia by AML1-ETO9a

  8. the eTAFH-E protein interaction appears to contribute relatively little to the activity of AML1 (show RUNX1 Proteins)-ETO

RUNX1T1 Protein Profile

Protein Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1)
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1)
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1)
  • AML1T1 protein
  • Cbfa2t1 protein
  • Cbfa2t1h protein
  • CDR protein
  • ETO protein
  • MTG8 protein
  • si:ch211-232j17.1 protein
  • wu:fi14b07 protein
  • zgc:154044 protein
  • ZMYND2 protein

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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