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Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Kits (14) and RUNX1 Proteins (7) and many more products for this protein.
Showing 10 out of 260 products:
Human Polyclonal RUNX1 Primary Antibody for EIA, WB - ABIN500646
Lee, Jenner, Boyer, Guenther, Levine, Kumar, Chevalier, Johnstone, Cole, Isono, Koseki, Fuchikami, Abe, Murray, Zucker, Yuan, Bell, Herbolsheimer, Hannett, Sun, Odom, Otte, Volkert, Bartel, Melton, Gifford, Jaenisch, Young: Control of developmental regulators by Polycomb in human embryonic stem cells. in Cell 2006
Show all 4 references for ABIN500646
Human Polyclonal RUNX1 Primary Antibody for FACS, IF - ABIN650732
Moosavi, Sanchez, Adeyinka: Marker chromosomes are a significant mechanism of high-level RUNX1 gene amplification in hematologic malignancies. in Cancer genetics and cytogenetics 2009
Show all 2 references for ABIN650732
Cow (Bovine) Polyclonal RUNX1 Primary Antibody for WB - ABIN2792647
Takeshita, Ichikawa, Nitta, Goyama, Asai, Ogawa, Chiba, Kurokawa: AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. in Leukemia 2008
Chicken Polyclonal RUNX1 Primary Antibody for WB - ABIN2780380
Ghozi, Bernstein, Negreanu, Levanon, Groner: Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. in Proceedings of the National Academy of Sciences of the United States of America 1996
Human Polyclonal RUNX1 Primary Antibody for ELISA, WB - ABIN1532121
Nucifora, Birn, Espinosa, Erickson, LeBeau, Roulston, McKeithan, Drabkin, Rowley: Involvement of the AML1 gene in the t(3,21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. in Blood 1993
Runx1 has an important role in Nf1 (show NF1 Antibodies) neurofibroma initiation
RUNX1 and ER occupy adjacent elements in AXIN1 (show AXIN1 Antibodies)'s second intron, and RUNX1 antagonizes oestrogen-mediated AXIN1 (show AXIN1 Antibodies) suppression.
A high level of Runx1 mRNA expression was detected on days 6-8 of pregnancy and under artificial decidualization. Data suggest that Runx1 may play an important role during mouse decidualization.
Results suggest that Runx1 is involved in targeting ventrocaudal hypoglossal neurons to specific muscles but is not necessary for neuronal survival, motoneuron specification, or synaptic development
Setbp1 (show SETBP1 Antibodies) overexpression also causes transcriptional repression of critical hematopoiesis regulator gene Runx1
Runx1-deficient hematopoietic stem and progenitor cells (HSPCs) have a slow growth, low biosynthetic, small cell phenotype and markedly reduced ribosome biogenesis.
mutation of the five Src (show SRC Antibodies)-modified residues to aspartate but not phenylalanine allows Runx1 to increase Cebpa (show CEBPA Antibodies) and granulocyte colony formation by Runx1-deleted murine marrow.
Runx1 is an important participant in the pathology of muscle wasting diseases.
Having characterized the extensive activity of P1, we utilized a P1-GFP homozygous mouse model to analyze the impact of the complete absence of Runx1 P1 expression in adult mice and observed strong defects in the T cell lineage.
Sox17 (show SOX17 Antibodies) inhibition of Runx1 and Gata2 (show GATA2 Antibodies) maintains endothelial fate in endothelial-to-haematopoietic transition
Germline RUNX1 mutations are associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia (show BCL11A Antibodies).
Two novel translocations leading to the inactivation of RUNX1 and its partners SIN3A (show SIN3A Antibodies) and TCF12 (show TCF12 Antibodies) in myeloid leukemia (show BCL11A Antibodies).
RUNX1-Evi-1 may promote proliferation and apoptosis resistance of primitive hematopoietic cell, and inhibit the differentiation of myeloid cells with the synergy of different pathways and factors.
Thus, an NGF (show NGFB Antibodies)/TrkA (show NTRK1 Antibodies)-MAPK (show MAPK1 Antibodies)-CBFbeta (show CBFB Antibodies) pathway converges with Islet1 (show ISL1 Antibodies)-Runx1 signaling to promote Runx1/CBFbeta (show CBFB Antibodies) holocomplex formation and nonpeptidergic nociceptor maturation.
Exon splicing patterns in the human RUNX1-RUNX1T1 (show RUNX1T1 Antibodies) fusion gene present in acute myeloid leukemia (show BCL11A Antibodies) patients have been decoded.
we observed that inhibition of RUNX1/ETO (show RUNX1T1 Antibodies) in Kasumi1 cells and in RUNX1/ETO (show RUNX1T1 Antibodies) positive primary acute myeloid leukemia (show BCL11A Antibodies) patient samples leads to up-regulation of miR144/451
Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1-ETO (show RUNX1T1 Antibodies)/RUNX1-RUNX1T1 (show RUNX1T1 Antibodies) is facilitated by interaction with the chaperonin (show HSPD1 Antibodies) TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70 (show HSP70 Antibodies)).
We conclude that the distal P1-Runx1 promoter is a direct transcriptional target of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling that may be important in normal hematopoiesis or its transition into malignant stem cells during the onset or progression of leukemia.
RUNX1 amplification may predispose to early thrombotic events in children with B-cell acute lymphoblastic leukemia
in hematopoietic cells RUNX1 protein is recruited to its own promoter to regulate RUNX1 gene transcription in a positive feedback loop.
Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development
We propose that cohesin and CTCF (show CTCF Antibodies) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.
Morpholino knockdown of Myef2 (show MYEF2 Antibodies) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.
Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta
in zebrafish adult HSCs can be formed without an intact runx1.
Zebrafish embryos lacking Rad21 (show RAD21 Antibodies), or cohesin subunit Smc3 (show SMC3 Antibodies), fail to express runx3 (show RUNX3 Antibodies) and lose hematopoietic runx1 expression in early embryonic development.
Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.
ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).
reveal a shift in Runx2 (show RUNX2 Antibodies) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.
runt-related transcription factor 1
, runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)
, runt-related transcription factor
, runt protein
, PEA2-alpha B
, PEBP2-alpha B
, SL3-3 enhancer factor 1 alpha B subunit
, SL3/AKV core-binding factor alpha B subunit
, acute myeloid leukemia 1 protein
, core binding factor alpha 2
, core-binding factor subunit alpha-2
, oncogene AML-1
, polyomavirus enhancer-binding protein 2 alpha B subunit
, runt domain, alpha subunit 2
, AML1-EVI-1 fusion protein
, core-binding factor, runt domain, alpha subunit 2
, runt-related transcription factor a
, Acute myeloid leukemia 1 protein
, Core-binding factor subunit alpha-2
, aml1 oncogene
, acute myeloid leukemia 1
, factor, runt domain, alpha subunit 2
, core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene)
, runt related transcription factor 1