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anti-Runt-Related Transcription Factor 1 (RUNX1) Antibodies

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Kits (14) and RUNX1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RUNX1 12394 Q03347
RUNX1 861 Q01196
RUNX1 50662 Q63046
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Top anti-RUNX1 Antibodies at antibodies-online.com

Showing 10 out of 267 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: PANC1 cell lysate WB Suggested Anti-RUNX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control: PANC1 cell lysate  There is BioGPS gene expression data showing that RUNX1 is expressed in PANC1 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate WB Suggested Anti-RUNX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: Jurkat cell lysate  RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Jurkat cell lysate WB Suggested Anti-RUNX1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control: Jurkat cell lysate  RUNX1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: SH-SYSY cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: PANC1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:7812500Positive Control: Human Small Intestine 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HepG2 cells treated with PMA 125ng/ml 30', using AML1 (Phospho-Ser435) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of RUNX1-S276 (ABIN650732) in K562 cell line lysates (35 µg/lane). RUNX1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with RUNX1 Antibody (S276) (ABIN650732), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of RUNX1 in Raji cell lysate with this product at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details

RUNX1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-RUNX1 Antibodies

  1. Human Polyclonal RUNX1 Primary Antibody for EIA, WB - ABIN500646 : Lee, Jenner, Boyer, Guenther, Levine, Kumar, Chevalier, Johnstone, Cole, Isono, Koseki, Fuchikami, Abe, Murray, Zucker, Yuan, Bell, Herbolsheimer, Hannett, Sun, Odom, Otte, Volkert, Bartel, Melton, Gifford, Jaenisch, Young: Control of developmental regulators by Polycomb in human embryonic stem cells. in Cell 2006 (PubMed)
    Show all 4 references for ABIN500646

  2. Human Polyclonal RUNX1 Primary Antibody for FACS, IF - ABIN650732 : Moosavi, Sanchez, Adeyinka: Marker chromosomes are a significant mechanism of high-level RUNX1 gene amplification in hematologic malignancies. in Cancer genetics and cytogenetics 2009 (PubMed)
    Show all 2 references for ABIN650732

  3. Cow (Bovine) Polyclonal RUNX1 Primary Antibody for WB - ABIN2792647 : Takeshita, Ichikawa, Nitta, Goyama, Asai, Ogawa, Chiba, Kurokawa: AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. in Leukemia 2008 (PubMed)

  4. Human Polyclonal RUNX1 Primary Antibody for ELISA, WB - ABIN1532121 : Nucifora, Birn, Espinosa, Erickson, LeBeau, Roulston, McKeithan, Drabkin, Rowley: Involvement of the AML1 gene in the t(3,21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. in Blood 1993 (PubMed)

  5. Chicken Polyclonal RUNX1 Primary Antibody for WB - ABIN2780380 : Ghozi, Bernstein, Negreanu, Levanon, Groner: Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)

More Antibodies against RUNX1 Interaction Partners

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Runx1 haploinsufficiency appears to predispose FPD patients to MM by expanding the pool of stem/progenitor cells and blocking myeloid differentiation in response to G-CSF (show CSF3 Antibodies).

  2. Runx1 has an important role in Nf1 (show NF1 Antibodies) neurofibroma initiation

  3. RUNX1 and ER occupy adjacent elements in AXIN1 (show AXIN1 Antibodies)'s second intron, and RUNX1 antagonizes oestrogen-mediated AXIN1 (show AXIN1 Antibodies) suppression.

  4. A high level of Runx1 mRNA expression was detected on days 6-8 of pregnancy and under artificial decidualization. Data suggest that Runx1 may play an important role during mouse decidualization.

  5. Results suggest that Runx1 is involved in targeting ventrocaudal hypoglossal neurons to specific muscles but is not necessary for neuronal survival, motoneuron specification, or synaptic development

  6. Setbp1 (show SETBP1 Antibodies) overexpression also causes transcriptional repression of critical hematopoiesis regulator gene Runx1

  7. Runx1-deficient hematopoietic stem and progenitor cells (HSPCs) have a slow growth, low biosynthetic, small cell phenotype and markedly reduced ribosome biogenesis.

  8. mutation of the five Src (show SRC Antibodies)-modified residues to aspartate but not phenylalanine allows Runx1 to increase Cebpa (show CEBPA Antibodies) and granulocyte colony formation by Runx1-deleted murine marrow.

  9. Runx1 is an important participant in the pathology of muscle wasting diseases.

  10. Having characterized the extensive activity of P1, we utilized a P1-GFP homozygous mouse model to analyze the impact of the complete absence of Runx1 P1 expression in adult mice and observed strong defects in the T cell lineage.

Human Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. ETV6 (show ETV6 Antibodies)/RUNX1 transcript is a target of RNA-binding protein (show PTBP1 Antibodies) IGF2BP1 (show IGF2BP1 Antibodies) in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia.

  2. Runx1 haploinsufficiency appears to predispose FPD patients to MM by expanding the pool of stem/progenitor cells and blocking myeloid differentiation in response to G-CSF (show CSF3 Antibodies).

  3. RUNX1 haploinsufficiency collaborates with genetic alterations conferring clonal advantage such as TET2 (show TET2 Antibodies) mutation or trisomy 21 to establish pre-leukemic state.

  4. The study shows a low representation of ETV6 (show ETV6 Antibodies)-RUNX1 fusion oncogenes among pediatric acute lymphoblastic leukemia patients from King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.

  5. Germline RUNX1 mutations are associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia (show BCL11A Antibodies).

  6. Two novel translocations leading to the inactivation of RUNX1 and its partners SIN3A (show SIN3A Antibodies) and TCF12 (show TCF12 Antibodies) in myeloid leukemia (show BCL11A Antibodies).

  7. RUNX1-Evi-1 may promote proliferation and apoptosis resistance of primitive hematopoietic cell, and inhibit the differentiation of myeloid cells with the synergy of different pathways and factors.

  8. Thus, an NGF (show NGFB Antibodies)/TrkA (show NTRK1 Antibodies)-MAPK (show MAPK1 Antibodies)-CBFbeta (show CBFB Antibodies) pathway converges with Islet1 (show ISL1 Antibodies)-Runx1 signaling to promote Runx1/CBFbeta (show CBFB Antibodies) holocomplex formation and nonpeptidergic nociceptor maturation.

  9. Exon splicing patterns in the human RUNX1-RUNX1T1 (show RUNX1T1 Antibodies) fusion gene present in acute myeloid leukemia (show BCL11A Antibodies) patients have been decoded.

  10. we observed that inhibition of RUNX1/ETO (show RUNX1T1 Antibodies) in Kasumi1 cells and in RUNX1/ETO (show RUNX1T1 Antibodies) positive primary acute myeloid leukemia (show BCL11A Antibodies) patient samples leads to up-regulation of miR144/451

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

  2. We propose that cohesin and CTCF (show CTCF Antibodies) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

  3. Morpholino knockdown of Myef2 (show MYEF2 Antibodies) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

  4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

  5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

  6. in zebrafish adult HSCs can be formed without an intact runx1.

  7. Zebrafish embryos lacking Rad21 (show RAD21 Antibodies), or cohesin subunit Smc3 (show SMC3 Antibodies), fail to express runx3 (show RUNX3 Antibodies) and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) interaction partners

  1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

  2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

  3. reveal a shift in Runx2 (show RUNX2 Antibodies) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage

RUNX1 Antigen Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX1

  • runt-related transcription factor 1 (RUNX1) antibody
  • runt-related transcription factor (runt) antibody
  • runt related transcription factor 1 (Runx1) antibody
  • runt-related transcription factor 1 (runx1) antibody
  • runt-related transcription factor 1 (Runx1) antibody
  • AI462102 antibody
  • aml antibody
  • aml-1 antibody
  • Aml1 antibody
  • aml1-evi-1 antibody
  • amlcr1 antibody
  • cbfa2 antibody
  • evi-1 antibody
  • Pebp2a2 antibody
  • pebp2ab antibody
  • Pebpa2b antibody
  • Runx-1 antibody
  • runx1 antibody
  • runxa antibody
  • XAML antibody
  • Xaml1 antibody

Protein level used designations for RUNX1

runt-related transcription factor 1 , runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) , runt-related transcription factor , runt protein , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core binding factor alpha 2 , core-binding factor subunit alpha-2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit , runt domain, alpha subunit 2 , AML1-EVI-1 fusion protein , core-binding factor, runt domain, alpha subunit 2 , aml1 , runt-related transcription factor a , runx1a , Acute myeloid leukemia 1 protein , Core-binding factor subunit alpha-2 , aml1 oncogene , ch-runtB2 , acute myeloid leukemia 1 , factor, runt domain, alpha subunit 2 , core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene) , runt related transcription factor 1

GENE ID SPECIES
473981 Pan troglodytes
100302713 Saccoglossus kowalevskii
12394 Mus musculus
861 Homo sapiens
58126 Danio rerio
379657 Xenopus laevis
396152 Gallus gallus
487746 Canis lupus familiaris
529631 Bos taurus
50662 Rattus norvegicus
100512633 Sus scrofa
100724149 Cavia porcellus
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