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Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping RUNX1 Kits (14) and RUNX1 Proteins (7) and many more products for this protein.
Showing 10 out of 271 products:
Human Polyclonal RUNX1 Primary Antibody for EIA, WB - ABIN500646
Lee, Jenner, Boyer, Guenther, Levine, Kumar, Chevalier, Johnstone, Cole, Isono, Koseki, Fuchikami, Abe, Murray, Zucker, Yuan, Bell, Herbolsheimer, Hannett, Sun, Odom, Otte, Volkert, Bartel, Melton, Gifford, Jaenisch, Young: Control of developmental regulators by Polycomb in human embryonic stem cells. in Cell 2006
Show all 4 references for ABIN500646
Human Polyclonal RUNX1 Primary Antibody for FACS, IF - ABIN650732
Moosavi, Sanchez, Adeyinka: Marker chromosomes are a significant mechanism of high-level RUNX1 gene amplification in hematologic malignancies. in Cancer genetics and cytogenetics 2009
Show all 2 references for ABIN650732
Cow (Bovine) Polyclonal RUNX1 Primary Antibody for IHC, WB - ABIN2792598
Takeshita, Ichikawa, Nitta, Goyama, Asai, Ogawa, Chiba, Kurokawa: AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1. in Leukemia 2008
Human Polyclonal RUNX1 Primary Antibody for ELISA, WB - ABIN1532121
Nucifora, Birn, Espinosa, Erickson, LeBeau, Roulston, McKeithan, Drabkin, Rowley: Involvement of the AML1 gene in the t(3,21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. in Blood 1993
Chicken Polyclonal RUNX1 Primary Antibody for WB - ABIN2780380
Ghozi, Bernstein, Negreanu, Levanon, Groner: Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions. in Proceedings of the National Academy of Sciences of the United States of America 1996
Runx1 deficiency enhanced CGRP expression and disrupted BMP4-induced neurite outgrowth inhibition in DRG.
Runx1 could be manipulated after injury to promote neuronal differentiation to facilitate repair of the CNS.
Runx1 haploinsufficiency appears to predispose FPD patients to MM by expanding the pool of stem/progenitor cells and blocking myeloid differentiation in response to G-CSF (show CSF3 Antibodies).
Runx1 has an important role in Nf1 (show NF1 Antibodies) neurofibroma initiation
RUNX1 and ER occupy adjacent elements in AXIN1 (show AXIN1 Antibodies)'s second intron, and RUNX1 antagonizes oestrogen-mediated AXIN1 (show AXIN1 Antibodies) suppression.
A high level of Runx1 mRNA expression was detected on days 6-8 of pregnancy and under artificial decidualization. Data suggest that Runx1 may play an important role during mouse decidualization.
Results suggest that Runx1 is involved in targeting ventrocaudal hypoglossal neurons to specific muscles but is not necessary for neuronal survival, motoneuron specification, or synaptic development
Setbp1 (show SETBP1 Antibodies) overexpression also causes transcriptional repression of critical hematopoiesis regulator gene Runx1
Runx1-deficient hematopoietic stem and progenitor cells (HSPCs) have a slow growth, low biosynthetic, small cell phenotype and markedly reduced ribosome biogenesis.
mutation of the five Src (show SRC Antibodies)-modified residues to aspartate but not phenylalanine allows Runx1 to increase Cebpa (show CEBPA Antibodies) and granulocyte colony formation by Runx1-deleted murine marrow.
we identified rs2249650 and rs2268276 as new AML susceptibility-associated SNPs. Genome editing at rs2249650 and rs2268276 may be performed in future to uncover the effect of this potential RUNX1 enhancer region.
RUNX1 and FKBP7 (show FKBP7 Antibodies), involved in erythropoesis and muscle protein synthesis, respectively, are related to change in cardiorespiratory fitness in response to exercise.
HTLF (show FOXN2 Antibodies) is a RUNX1 target whose down-regulation promotes genomic instability and correlates with complex cytogenetic abnormalities in acute myeloid leukemia (show BCL11A Antibodies) patients.
High RUNX1 expression is associated with breast cancer.
The Leukemia Inhibitory Factor Receptor (show LIFR Antibodies) Gene Is a Direct Target of RUNX1
the tumor-suppressor runt domain transcription factor 1 (show HNF1A Antibodies) (RUNX1) was confirmed to be a downstream molecule of H19 (show NCKAP1 Antibodies)/miR (show MLXIP Antibodies)-675 axis, since overexpression of H19 (show NCKAP1 Antibodies) or miR (show MLXIP Antibodies)-675 significantly decreased RUNX1 expression in Gastric Cancer cells
Low expression of RUNX1 is associated with malignant progression of gastric cancer.
ETV6 (show ETV6 Antibodies)/RUNX1 transcript is a target of RNA-binding protein (show PTBP1 Antibodies) IGF2BP1 (show IGF2BP1 Antibodies) in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia.
RUNX1 haploinsufficiency collaborates with genetic alterations conferring clonal advantage such as TET2 (show TET2 Antibodies) mutation or trisomy 21 to establish pre-leukemic state.
Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development
We propose that cohesin and CTCF (show CTCF Antibodies) have distinct functions in the regulation of runx1 during zebrafish embryogenesis.
Morpholino knockdown of Myef2 (show MYEF2 Antibodies) or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.
Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta
in zebrafish adult HSCs can be formed without an intact runx1.
Zebrafish embryos lacking Rad21 (show RAD21 Antibodies), or cohesin subunit Smc3 (show SMC3 Antibodies), fail to express runx3 (show RUNX3 Antibodies) and lose hematopoietic runx1 expression in early embryonic development.
Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.
ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).
reveal a shift in Runx2 (show RUNX2 Antibodies) function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.
runt-related transcription factor 1
, runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)
, runt-related transcription factor
, runt protein
, PEA2-alpha B
, PEBP2-alpha B
, SL3-3 enhancer factor 1 alpha B subunit
, SL3/AKV core-binding factor alpha B subunit
, acute myeloid leukemia 1 protein
, core binding factor alpha 2
, core-binding factor subunit alpha-2
, oncogene AML-1
, polyomavirus enhancer-binding protein 2 alpha B subunit
, runt domain, alpha subunit 2
, AML1-EVI-1 fusion protein
, core-binding factor, runt domain, alpha subunit 2
, runt-related transcription factor a
, Acute myeloid leukemia 1 protein
, Core-binding factor subunit alpha-2
, aml1 oncogene
, acute myeloid leukemia 1
, factor, runt domain, alpha subunit 2
, core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene)
, runt related transcription factor 1