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Runt-Related Transcription Factor 2 Proteins (RUNX2)

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Additionally we are shipping RUNX2 Antibodies (201) and RUNX2 Kits (49) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX2 12393 Q08775
RUNX2 860 Q13950
RUNX2 367218  
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Top RUNX2 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$820.60
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$862.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Horse His tag   1 mg Log in to see 56 to 66 Days
$2,271.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,541.00
Details
HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 9 to 11 Days
$229.85
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,030.69
Details

RUNX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,
Rat (Rattus)

More Proteins for Runt-Related Transcription Factor 2 (RUNX2) Interaction Partners

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. our studies reveal a novel function for Runx2 in regulating mammary epithelial cell regenerative potential, possibly acting as a downstream target of WNT (show WNT2 Proteins) signalling.

  2. MED23 (show MED23 Proteins) binds to RUNX2 and modulates its transcriptional activity.

  3. Hand1 (show HAND1 Proteins) downregulated Ihh (show IHH Proteins) gene expression in vitro by inhibiting Runx2 transactivation of the Ihh (show IHH Proteins) proximal promoter.

  4. increased intranuclear actin forces MSC (show MSC Proteins) into osteogenic lineage through controlling Runx2 activity; this process may be useful for clinical objectives of forming bone.

  5. We observed that tranilast increased mRNA expression of both Sox9 (show SOX9 Proteins) and Runx2 in differentiating ATDC5 chondrogenic progenitor cells.

  6. Results propose that Utx (show KDM6A Proteins) plays important roles in osteoblast differentiation by controlling the expressions of Runx2 and Osterix (show SP7 Proteins).

  7. Somatic transmission of Runx2 mRNAs in osteoblasts and osteosarcoma cells represents a versatile mechanism for translational rather than transcriptional induction.

  8. The data indicate a critical role of Runx2 in Smooth muscle cell (SMC (show DYM Proteins)) osteogenic phenotype change and mineral deposition in a mouse model of Arterial medial calcification (AMC).

  9. Gene expression of Tau, a neuronal phosphoprotein with important roles in neuronal biology and microtubule dynamics and assembly, was high in wild-type molars but severely reduced in transgenic(Col1a1 (show COL1A1 Proteins)-Runx2) molars.

  10. Runx2/miR (show MLXIP Proteins)-3960/miR (show MLXIP Proteins)-2861 positive feedback loop plays an important role in osteogenic transdifferentiation of vascular smooth muscle cells and contributes to vascular calcification.

Human Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2-Osterix (show SP7 Proteins)-BSP (show KLK6 Proteins) Signaling.

  2. Runx2 activation by BMP signaling mediates serum deprivation triggers upregulation of hST3Gal V gene expression in MG-63 cells.

  3. GnRH (show GNRH1 Proteins) regulates trophoblast invasion via RUNX2-mediated MMP2 (show MMP2 Proteins)/MMP9 (show MMP9 Proteins) expression.

  4. An osteogenic medium is required for the differentiation of adul tmesenchymal stem cells, which is also under RUNX2 regulation. These findings are potentially valuable for clinical practice.

  5. This integrative genomic study confirmed the role of RUNX2 as a potential driver of AS and identified a new AS susceptibility gene, CACNA1C (show CACNA1C Proteins), belonging to the calcium signaling pathway.

  6. It is suggested that oxytalan-positive POFs, purportedly originating from the periodontal ligament, express molecules that are specific to bone and cementum (Runx-2, BMP-2 (show BMP2 Proteins)), or cementum only (CAP).

  7. results reveal the regulatory circuit between RUNX2 and SMURF1 (show SMURF1 Proteins) controls RUNX2 expression and regulates odntoblastic differentiation in hDPSCs.

  8. Data suggest that RUNX2 transcription factor:TAZ transcriptional co-activator and activation of sE-Cadherin/proto-oncogene (show RAB1A Proteins) protein HER-2 (show ERBB2 Proteins) signaling could be potential oncogenic pathways for breast cancer (BC) metastasis.

  9. RUNX2 mediates epigenetic regulation of the survival of p53 (show TP53 Proteins) defective osteosarcoma cells.

  10. Studies indicate the involvement of estrogen signaling in breast cancer development and the interaction between RUNX2 and estrogen-dependent pathways can contribute to the mechanisms involved in cancer transformation. [review]

Rabbit Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. The OPG (show TNFSF11 Proteins) expression levels decreased while those of RANKL (show TNFSF11 Proteins) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. These data also indicate that MGP (show MGP Proteins) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

RUNX2 Protein Profile

Protein Summary

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Gene names and symbols associated with RUNX2

  • runt-related transcription factor 2a (runx2a)
  • transcription factor Cbfa1 (runx2)
  • runt-related transcription factor 2 (RUNX2)
  • runt-related transcription factor 2 (runx2)
  • runt related transcription factor 2 (Runx2)
  • runt-related transcription factor 2 (Runx2)
  • runt-related transcription factor 2 (LOC100339156)
  • runt-related transcription factor 2-like (LOC100737965)
  • AML3 protein
  • Cbf protein
  • CBF-alpha-1 protein
  • Cbfa-1 protein
  • CBFA1 protein
  • CCD protein
  • CCD1 protein
  • CLCD protein
  • LS3 protein
  • OSF-2 protein
  • OSF2 protein
  • PEA2aA protein
  • Pebp2a1 protein
  • pebp2a2 protein
  • PEBP2aA protein
  • pebp2aa1 protein
  • Pebpa2a protein
  • RUNX2 protein

Protein level used designations for RUNX2

runt-related transcription factor 2 , transcription factor Runx2a , transcription factor Cbfa1 , runt-related transcription factor 2-like , AKV core binding factor , CBF-alpha-1 , PEA2-alpha A , PEBP2 alpha A , SL3-3 enhancer factor 1 alpha A subunit , acute myeloid leukemia 3 protein , core binding factor alpha 1 , osteoblast-specific transcription factor 2 , polyomavirus enhancer-binding protein 2 alpha A subunit , runt domain, alpha subunit 1 , PEBP2-alpha A , SL3/AKV core-binding factor alpha A subunit , core-binding factor, runt domain, alpha subunit 1 , oncogene AML-3 , runt-related factor 2 , core-binding factor subunit alpha-1 , runt related transcription factor 2 , Runx2 spliced isoform , runt-related transcription factor 2 type I , runt-related transcription factor 2 type II , core binding factor alpha 1 subunit

GENE ID SPECIES
405784 Danio rerio
445986 Takifugu rubripes
449531 Canis lupus familiaris
472017 Pan troglodytes
703331 Macaca mulatta
100080409 Ornithorhynchus anatinus
100189546 Xenopus (Silurana) tropicalis
100222668 Taeniopygia guttata
100406564 Callithrix jacchus
100453201 Pongo abelii
100549663 Meleagris gallopavo
100555776 Anolis carolinensis
100619969 Monodelphis domestica
12393 Mus musculus
860 Homo sapiens
474923 Canis lupus familiaris
536911 Bos taurus
100008943 Oryctolagus cuniculus
367218 Rattus norvegicus
100037059 Xenopus laevis
373919 Gallus gallus
100734175 Cavia porcellus
100033890 Equus caballus
100155806 Sus scrofa
100339156 Oryctolagus cuniculus
100861217 Capra hircus
101115489 Ovis aries
100737965 Sus scrofa
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