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Runt-Related Transcription Factor 3 Proteins (RUNX3)

RUNX3 encodes a member of the runt domain-containing family of transcription factors. Additionally we are shipping RUNX3 Antibodies (181) and RUNX3 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RUNX3 12399  
RUNX3 864 Q13761
RUNX3 156726  
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Top RUNX3 Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$5,769.50
Details
HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 11 to 13 Days
$352.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details
Human Un-conjugated   2 μg Log in to see 6 Days
$168.54
Details

RUNX3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)
,
Human ,
,
Rat (Rattus)

Top referenced RUNX3 Proteins

  1. Human RUNX3 Protein expressed in Escherichia coli (E. coli) - ABIN667137 : Li, Ito, Sakakura, Fukamachi, Inoue, Chi, Lee, Nomura, Lee, Han, Kim, Kim, Yamamoto, Yamashita, Yano, Ikeda, Itohara, Inazawa, Abe, Hagiwara, Yamagishi, Ooe, Kaneda, Sugimura, Ushijima, Bae, Ito: Causal relationship between the loss of RUNX3 expression and gastric cancer. in Cell 2002 (PubMed)
    Show all 2 references for ABIN667137

More Proteins for Runt-Related Transcription Factor 3 (RUNX3) Interaction Partners

Zebrafish Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. successive induction of the transcription factors Runx3, Egr1 and Sox9b constitutes a regulatory cascade that controls expression of Follistatin A in pharyngeal endoderm, the latter modulating BMP signaling in developing cranial cartilage in zebrafish

  2. Runx3 expression leads to an increase in primitive blood cell numbers, together with an increase in runx1 (show RUNX1 Proteins)-expressing cells in the ventral wall of the dorsal aorta.

  3. Zebrafish embryos lacking Rad21 (show RAD21 Proteins), or cohesin subunit Smc3 (show SMC3 Proteins), fail to express runx3 and lose hematopoietic runx1 (show RUNX1 Proteins) expression in early embryonic development.

Mouse (Murine) Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. our data suggest that Runx3 may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 (show NTRK3 Proteins) variants

  2. Runx3 is crucial for the phenotypic and functional changes observed in ThPok (show ZBTB7B Proteins)-deficient invariant natural killer T cells.

  3. the transcription factor Runx3 was essential for the normal development of subsets of innate lymphoid cells (ILCs) in the mucosa

  4. Runx1 and Runx3 are the downstream effectors of Nanog, especially in the early and intermediate osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2.

  5. nonpermissive expression of RUNX3 protein is restricted at the translational level, and that the repression is further enforced by a transcriptional regulation for maintenance of diverse developmental plasticity of T cells for different effector subsets.

  6. Our findings establish Nr4a1 (show NR4A1 Proteins) as a novel and critical player in the regulation of CD8 (show CD8A Proteins) T cell development through the direct suppression of Runx3.

  7. Runx1 Runx3 DKO mice exhibit bone marrow failure and myeloproliferative disorder. RUNX proteins are important for FANCD2 recruitment to DNA repair foci.

  8. inflammation-mediated tumor promotion requires leukocytic Runx3 expression

  9. Bone histomorphometry revealed that decreased osteoblast numbers and reduced mineral deposition capacity in Runx3-deficient mice cause this bone formation deficiency.

  10. RUNX3 expression suppresses metastasis and angiogenesis of human prostate cancer.

Human Runt-Related Transcription Factor 3 (RUNX3) interaction partners

  1. miR (show MLXIP Proteins)-20a overexpression contributed to hepatocellular carcinoma cell proliferation and migration through reducing the translation of RUNX3.

  2. RUNX3 plays an important role in As2O3induced cellular responses and allows cells to overcome mesenchymal stem cellmediated drug resistance

  3. Results confirmed that a loss of RUNX3 in esophageal squamous cell carcinoma may contribute to cisplatin-resistance.

  4. The RUNX3 gene promoter methylation rate was much higher in tumor tissue than that in normal gastric tissue in patient with gastric cancer, which indicates a close association between gastric cancer and RUNX3 gene promoter methylation.

  5. RUNX3 overexpression inhibited CRC cell migration and invasion resulting from the upregulation of matrix metalloproteinase-2 (MMP-2) and MMP-9 expression. the knockdown of RUNX3 reduced the inhibition of migration and invasion of CRC cells. Finally, we found that restoration of RUNX3 decreased vascular endothelial growth factor (VEGF) secretion and suppressed endothelial cell growth and tube formation

  6. RUNX3 promoter methylation is linked to the origin of HCC (show FAM126A Proteins) but not to its progression from non-metastatic to metastatic stages.

  7. hypermethylation modifications of CpG13, CpG14, and CpG15 (show NRN1 Proteins) in the promoter region of Runx3 could result in the down regulation of Runx3 expression to affect the prognosis of Chronic Atrophic Gastritis Patients. So the methylation levels of these CpG sites in Runx3 in the peripheral blood can be used as the biomarker for predicting the healing prognosis of Chronic Atrophic Gastritis Patients patients.

  8. miR (show MLXIP Proteins)-148a-3p may regulate RUNX3 expression through the modulation of DNMT1 (show DNMT1 Proteins)-dependent DNA methylation (show HELLS Proteins) in laryngeal squamous cell carcinoma.

  9. miR (show MLXIP Proteins)-130b expression was downregulated, while RUNX3 mRNA was upregulated, in EOC tissues compared to normal ovarian tissues (both P=0.001). Importantly, the expression level of miR (show MLXIP Proteins)-130b in EOC tissues was negatively correlated with that of RUNX3 mRNA significantly.

  10. N-myc protein (show MYCN Proteins) also could bind to the promoter of pri-miR (show MLXIP Proteins)-4295 and inhibit the expression of RUNX3 in glioma cells.

RUNX3 Protein Profile

Protein Summary

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with RUNX3

  • runt-related transcription factor 3 (runx3)
  • runt-related transcription factor 3 (RUNX3)
  • frRunx3/p45 (frrunx3)
  • runt related transcription factor 3 (Runx3)
  • runt-related transcription factor 3 (Runx3)
  • AML2 protein
  • Cbfa3 protein
  • frrunx3 protein
  • Pebp2a3 protein
  • PEBP2aC protein
  • runx3 protein
  • runxb protein

Protein level used designations for RUNX3

runt-related transcription factor b , runt-related transcription factor 3 , core-binding factor 3 , frRunx3/p45 , CBF-alpha-3 , PEA2-alpha C , PEBP2-alpha C , SL3-3 enhancer factor 1 alpha C subunit , SL3/AKV core-binding factor alpha C subunit , acute myeloid leukemia 2 protein , core binding factor alpha 3 , core-binding factor subunit alpha-3 , oncogene AML-2 , polyomavirus enhancer-binding protein 2 alpha C subunit , runt domain, alpha subunit 3 , transcription factor AML2/CBFA3 , PEA2 alpha C , PEBP2 alpha C , acute myeloid leukemia gene 2 , core-binding factor, runt domain, alpha subunit 3 , transcription factor AML2 , Runt related transcription factor 3 , Runx3 MASN-variant

GENE ID SPECIES
58127 Danio rerio
403159 Sus scrofa
456633 Pan troglodytes
100049632 Takifugu rubripes
100474431 Ailuropoda melanoleuca
100500732 Xenopus laevis
12399 Mus musculus
864 Homo sapiens
617389 Bos taurus
156726 Rattus norvegicus
769687 Gallus gallus
487366 Canis lupus familiaris
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