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S100 Calcium Binding Protein A8 (Calgranulin A) Proteins (S100A8)

The protein encoded by S100A8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping S100A8 Antibodies (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Human S100A8 S100A8 85320 Q96J66
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Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 5 Days

S100A8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

More Proteins for S100 Calcium Binding Protein A8 (Calgranulin A) (S100A8) Interaction Partners

Human S100 Calcium Binding Protein A8 (Calgranulin A) (S100A8) interaction partners

  1. MRP8 elevated serum levels in patients with Behcet's disease indicate MRP8 role in the pathogenetic mechanisms of Behcet's disease.

  2. The ABCC11 gene SNP of the 538 G>A allele was associated with a downregulation of the mRNA expression of ApoD (show APOD Proteins) in the apocrine glands, which may indicate a role for the ABCC11 gene in the mediation of osmidrosis

  3. study revealed a novel role of MRP8/14 in the autophagy-mediated elimination of intracellular BCG (show SLC11A1 Proteins) by promoting reactive oxygen species generation

  4. Circulating MRP-8/14 is associated with TX-dependent platelet activation in ACS (show PLA2G15 Proteins), even during low-dose aspirin treatment, suggesting a contribution of residual TX to MRP-8/14 shedding, which may further amplify platelet activation.

  5. Data suggest that tissue infiltrating macrophages secreting MRP8/14 may contribute to myositis, by driving the local production of cytokines directly from muscle.

  6. MRP8/14 can activate cells by binding to TLR4 (show TLR4 Proteins), leading to the release of proinflammatory cytokines. These mediators can lead to increased disease activity in enthesitis-related arthritis.

  7. Our results suggest that a specific type of toxicity, leukopenia, is associated with a particular variant of ABCC11, which is different from the earwax and eQTL (show EQTN Proteins) variants.

  8. High baseline serum MRP8/14 levels are associated with lower survival in Chinese peritoneal dialysis patients.

  9. MRP8 has a crucial role in stimulating IL-6 (show IL6 Proteins) expression by rheumatoid arthritis fibroblast-like synoviocytes.

  10. High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival.

S100A8 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with S100A8

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 11 (ABCC11)
  • EWWD protein
  • MRP8 protein
  • WW protein

Protein level used designations for S100A8

ATP-binding cassette protein C11 , ATP-binding cassette sub-family C member 11 , ATP-binding cassette transporter MRP8 , ATP-binding cassette transporter sub-family C member 11 , multi-resistance protein 8 , multidrug resistance-associated protein 8

85320 Homo sapiens
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