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SAMHD1 may play a role in regulation of the innate immune response. Additionally we are shipping SAMHD1 Kits (7) and SAMHD1 Proteins (4) and many more products for this protein.
Showing 10 out of 107 products:
Human Monoclonal SAMHD1 Primary Antibody for FACS, IF - ABIN2453908
Zhang, Bloch, Nguyen, Kim, Landau: SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells. in PLoS ONE 2014
Show all 2 references for ABIN2453908
Human Monoclonal SAMHD1 Primary Antibody for FACS, IF - ABIN2453623
Tabler, Lucera, Haqqani, McDonald, Migueles, Connors, Tilton: CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression. in Journal of virology 2014
Show all 2 references for ABIN2453623
Human Polyclonal SAMHD1 Primary Antibody for ICC, IF - ABIN441436
Nomaguchi, Doi, Adachi: Virological characterization of HIV-2 vpx gene mutants in various cell systems. in Microbes and infection 2014
Interferonstimulated gene factor 3 complex, which consists of STAT1 (show STAT1 Antibodies), STAT2 (show STAT2 Antibodies) and IRF9 (show IRF9 Antibodies), is required for the induction of SAMHD1 expression by IFN-alpha (show IFNA Antibodies) in SMMC-7721 cells.
Studied whether one or more SAMHD1 gene mutations are associated with cerebrovascular disease in the general population using a Chinese stroke cohort.
SAMHD1 may facilitate some aspects of THP-1 (show GLI2 Antibodies) cell differentiation.
Therefore, our findings revealed that factors in addition to Vpx-SAMHD1 binding influence the efficiency of Vpx-mediated SAMHD1 degradation.
These results argue against a requirement for additional myeloid-specific host factors for SAMHD1 function but further support the notion that SAMHD1 possesses an additional dNTP-independent function contributing to lentiviral restriction.
This review summarizes the latest advances in understanding the importance of dNTP metabolism in cancer development and the novel function of SAMHD1 in regulating this process.
SAMHD1 phosphorylation also ablates restriction and tetramer formation but without affecting triphosphohydrolase steady-state kinetics
Data suggest that critical role of vpx (Simian immunodeficiency virus vpx protein) in vivo/in vitro is to promote degradation of SAMHD1 in memory CD4 (show CD4 Antibodies)+ T-lymphocytes, thereby generating high levels of plasma viremia and induction of immunodeficiency.
increased SAMHD1 in human astrocytes is in part responsible for the HIV restriction, silencing of which relieves this restriction
The results presented herein suggest that the RNase activity of SAMHD1 is sufficient to control the replication of retroviruses, but not that of non-retro RNA viruses.
Data suggest that zebrafish may represent a system for studying the relationship between type I interferon (show IFNA Antibodies) (IFN) signaling and a loss of deoxynucleoside triphosphate triphosphohydrolase SAMHD1 activity.
SAMHD1 in the mouse blocks retroviral infection at the level of reverse transcription and is regulated through cell cycle-dependent phosphorylation.
phosphorylation of mSAMHD1 at T634 by CDK1 (show CDK1 Antibodies)/2 negatively regulates its HIV-1 restriction in differentiated cells, but does not affect its murine leukemia virus restriction in dividing cells.
SAMHD1 restricts HIV-1 replication and regulates interferon (show IFNA Antibodies) production in mouse myeloid cells.
Allosteric regulation by dATP and dTTP works similarly in human and mouse SAMHD1.
SAMHD1 decreases dNTP pool in murine cells, restricts retroviral replication and regulates type I IFN production.
SAMHD1 can restrict lentiviruses in vivo and that nucleotide starvation is an evolutionarily conserved antiviral mechanism.
there are several Vpx residues required for SAMHD1 degradation
Vpx targets SAMHD1 for degradation in a viral strategy to control cellular deoxynucleotide levels for efficient replication
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
SAM domain and HD domain-containing protein 1
, dendritic cell-derived IFNG-induced protein
, deoxynucleoside triphosphate triphosphohydrolase SAMHD1
, monocyte protein 5
, SAM domain- and HD domain-containing protein 1
, IFN-gamma induced
, interferon-gamma-inducible protein Mg11