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SAMHD1 may play a role in regulation of the innate immune response. Additionally we are shipping SAMHD1 Kits (5) and SAMHD1 Proteins (4) and many more products for this protein.
Showing 10 out of 109 products:
Human Monoclonal SAMHD1 Primary Antibody for FACS, IF - ABIN2453908
Zhang, Bloch, Nguyen, Kim, Landau: SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells. in PLoS ONE 2014
Show all 2 references for ABIN2453908
Human Polyclonal SAMHD1 Primary Antibody for ICC, IF - ABIN441436
Nomaguchi, Doi, Adachi: Virological characterization of HIV-2 vpx gene mutants in various cell systems. in Microbes and infection 2014
Show all 2 references for ABIN441436
Human Monoclonal SAMHD1 Primary Antibody for FACS, IF - ABIN2453623
Tabler, Lucera, Haqqani, McDonald, Migueles, Connors, Tilton: CD4+ memory stem cells are infected by HIV-1 in a manner regulated in part by SAMHD1 expression. in Journal of virology 2014
Show all 2 references for ABIN2453623
Our findings will facilitate more advanced studies into the role of the SAMHD1 RNase function in the cellular pathogenesis implicated in nucleic acid-triggered inflammatory responses and the anti-retroviral function of SAMHD1.
Comparison of the wild-type SAMHD1 and the T592D mutant reveals that the phosphomimetic mutation affects the rates of tetramer dissociation, but has no effect on the equilibrium of allosteric activation by deoxynucleotides.
data suggest an antagonistic regulatory mechanism in which the mutually exclusive oligomeric state requirements for ssNA binding and dNTP hydrolase activity modulate these two functions of SAMHD1 within the cell
These results indicate that SAMHD1 inhibits HBV replication at the reverse transcription step, most likely through the depletion of cellular dNTPs.
Our results suggest that SAMHD1, through its dNTPase activity, affects cell proliferation, cell cycle distribution and apoptosis, and emphasize a key role of SAMHD1 in the interplay between cell cycle regulation and HIV-1 infection.
This study reviewed that Neurologic Phenotypes Associated with Mutations in SAMHD1 in patients with Aicardi-Goutieres Syndrome.
cytokines play a major role in the reservoir establishment not only by driving homeostatic proliferation but also by increasing susceptibility of CD4 (show CD4 Antibodies)+ lymphocytes to HIV-1 infection through SAMHD1 inactivation.
These observations suggest that heterozygous cancer-associated SAMHD1 mutations increase mutation rates in cancer cells.
The SAMHD1 restricts HIV-1 infection in non-cycling cells by limiting the pool of deoxyribonucleoside triphosphates, thereby interfering with HIV-1 reverse transcription.
Interferonstimulated gene factor 3 complex, which consists of STAT1 (show STAT1 Antibodies), STAT2 (show STAT2 Antibodies) and IRF9 (show IRF9 Antibodies), is required for the induction of SAMHD1 expression by IFN-alpha (show IFNA Antibodies) in SMMC-7721 cells.
Data suggest that zebrafish may represent a system for studying the relationship between type I interferon (show IFNA Antibodies) (IFN) signaling and a loss of deoxynucleoside triphosphate triphosphohydrolase SAMHD1 activity.
SAMHD1 in the mouse blocks retroviral infection at the level of reverse transcription and is regulated through cell cycle-dependent phosphorylation.
phosphorylation of mSAMHD1 at T634 by CDK1 (show CDK1 Antibodies)/2 negatively regulates its HIV-1 restriction in differentiated cells, but does not affect its murine leukemia virus restriction in dividing cells.
SAMHD1 restricts HIV-1 replication and regulates interferon (show IFNA Antibodies) production in mouse myeloid cells.
Allosteric regulation by dATP and dTTP works similarly in human and mouse SAMHD1.
SAMHD1 decreases dNTP pool in murine cells, restricts retroviral replication and regulates type I IFN production.
SAMHD1 can restrict lentiviruses in vivo and that nucleotide starvation is an evolutionarily conserved antiviral mechanism.
there are several Vpx residues required for SAMHD1 degradation
Vpx targets SAMHD1 for degradation in a viral strategy to control cellular deoxynucleotide levels for efficient replication
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
SAM domain and HD domain-containing protein 1
, dendritic cell-derived IFNG-induced protein
, deoxynucleoside triphosphate triphosphohydrolase SAMHD1
, monocyte protein 5
, SAM domain- and HD domain-containing protein 1
, IFN-gamma induced
, interferon-gamma-inducible protein Mg11