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Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Additionally we are shipping SAR1A Proteins (17) and SAR1A Kits (3) and many more products for this protein.
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Human Polyclonal SAR1A Primary Antibody for FACS, IHC (p) - ABIN390902
Morgan, Turic, Jehu, Hamilton, Hollingworth, Moskvina, Jones, Lovestone, Brayne, Rubinsztein, Lawlor, Gill, ODonovan, Owen, Williams: Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007
Human Polyclonal SAR1A Primary Antibody for WB - ABIN375021
Bi, Mancias, Goldberg: Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31. in Developmental cell 2007
SAR1A gene silencing in hepatocytes mimics the effect of ethanol: dedimerization of giantin (show GOLGB1 Antibodies), arresting PDIA3 (show PDIA3 Antibodies) in the endoplasmic reticulum (ER) and large-scale alterations in Golgi architecture.
Data indicate that hydroxyurea (HU) induces SAR1 (show IQGAP1 Antibodies) protein expression, which in turn activates gamma-globin (show HBG1 Antibodies) expression, predominantly through the Gialpha/JNK (show MAPK8 Antibodies)/Jun (show JUN Antibodies) pathway.
although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B (show SAR1B Antibodies), both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo.
Sar1 (show IQGAP1 Antibodies) mutant proteins added to metaphase-arrested Xenopus laevis egg extracts cause dramatic effects on membrane organization.
the behavior of the human of Sar1A and Sar1B (show SAR1B Antibodies), a key component of the COPII family of vesicle coat proteins, was examined.
Sedlin (show TRAPPC2 Antibodies) bound and promoted efficient cycling of Sar1 (show IQGAP1 Antibodies), a guanosine triphosphatase that can constrict membranes, and thus allowed nascent carriers to grow and incorporate procollagen prefibrils.
lipid-directed and tether-assisted Sar1 (show IQGAP1 Antibodies) organization controls membrane constriction to regulate ER export.
the intracellular trafficking of hCaR (show CXADR Antibodies) from the endoplasmic reticulum is Sar1 (show IQGAP1 Antibodies)-dependent via coat protein (show GOLPH3 Antibodies) complex-II vesicles.
The Sec31 (show EXOC1 Antibodies) fragment stimulates GAP activity of Sec23/24, and a convergence of Sec31 (show EXOC1 Antibodies) and Sec23 residues at the Sar1 (show IQGAP1 Antibodies) GTPase (show RACGAP1 Antibodies) active site explains how GTP (show AK3 Antibodies) hydrolysis is triggered leading to COPII coat (show SEC23A Antibodies) disassembly.
Sar 1 (show IQGAP1 Antibodies) H79G mutants efficiently blocked the plasma membrane trafficking of the Kir3.1 (show KCNJ3 Antibodies)/Kir3.4 (show KCNJ5 Antibodies) complex however they did not block the Gbeta1gamma2/Kir3.1 (show KCNJ3 Antibodies) interaction.
Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity).
GTP-binding protein Sar1A
, GTP-binding protein SAR1a
, GTP-binding protein SAR1A
, SAR1a gene homolog 1
, COPII-associated small GTPase
, SAR1 gene homolog A