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anti-SEC63 Homolog (S. Cerevisiae) (SEC63) Antibodies

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Additionally we are shipping SEC63 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SEC63 11231 Q9UGP8
SEC63 309858  
SEC63 140740 Q8VHE0
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Top anti-SEC63 Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-SEC63 Antibody Titration: 0.2-1 ug/mlPositive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SEC63 Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Dog Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Un-conjugated IHC (p), WB SEC63 Antibody (N-term) (ABIN657052) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Biotin IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Mouse Un-conjugated IF, ELISA, WB Detection limit for recombinant GST tagged SEC63 is 1 ng/ml as a capture antibody. Western Blot analysis of SEC63 expression in transfected 293T cell line by SEC63 monoclonal antibody (M04), clone 1A8.Lane 1: SEC63 transfected lysate (Predicted MW: 36.52 KDa).Lane 2: Non-transfected lysate. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated WB SEC63 antibody used at 1.25 ug/ml to detect target protein. 100 μg Log in to see 3 to 4 Days
$388.93
Details

SEC63 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Rat (Rattus)


Mouse (Murine)


Top referenced anti-SEC63 Antibodies

  1. Human Polyclonal SEC63 Primary Antibody for WB - ABIN2782761 : You, Li, Kim, Kang, Koh, Chwae, Kim, Kim, Park, Jang, Kim: Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. in PLoS biology 2007 (PubMed)

  2. Chicken Polyclonal SEC63 Primary Antibody for WB - ABIN2773888 : Otsuki, Ota, Nishikawa, Hayashi, Suzuki, Yamamoto, Wakamatsu, Kimura, Sakamoto, Hatano, Kawai, Ishii, Saito, Kojima, Sugiyama, Ono, Okano, Yoshikawa, Aotsuka, Sasaki, Hattori, Okumura, Nagai, Sugano et al.: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. ... in DNA research : an international journal for rapid publication of reports on genes and genomes 2005 (PubMed)

More Antibodies against SEC63 Interaction Partners

Human SEC63 Homolog (S. Cerevisiae) (SEC63) interaction partners

  1. a SEC63 germline mutation may play a role in cyst formation in polycystic liver disease

  2. Phosphorylation of Sec63 by CK2 (show CSNK2A1 Antibodies) enhanced its binding to Sec62 (show TLOC1 Antibodies)

  3. Sec63 may perform a substrate-selective quantity control function during cotranslational endoplasmic reticulum import.

  4. Silencing the human SEC63 genes inhibits transport of only a subset of signal-peptide-containing precursor proteins to endoplasmic reticulum.

  5. identified nucleoredoxin (show NXN Antibodies) as an interaction partner of Sec63; characterized this interaction; Sec63 is linked to the Wnt (show WNT2 Antibodies) signaling pathways and this interaction may be the reason why mutations in SEC63 can lead to polycystic liver disease

  6. identified a total of 26 novel mutations in PRKCSH (show PRKCSH Antibodies) (n = 14) and SEC63 (n = 12), including four splice site mutations, eight insertions/ deletions, six non-sense mutations, and eight missense mutations

  7. Mutations in SEC63 cause autosomal dominant polycystic liver disease, suggesting a role for cotranslational protein-processing pathways in maintaining epithelial luminal structure and implicating noncilial ER proteins in human polycystic disease.

  8. Sec63p expression was observed in all cyst epithelia regardless of mutational state. And, Cystogenesis in SEC63-associated PCLD (show PRKCSH Antibodies) occurs via a different mechanism.

Zebrafish SEC63 Homolog (S. Cerevisiae) (SEC63) interaction partners

  1. disruption of sec63 leads to abnormalities in myelinating glia in both the central and peripheral nervous systems

Mouse (Murine) SEC63 Homolog (S. Cerevisiae) (SEC63) interaction partners

  1. SEC63 function regulates IRE1alpha (show ERN1 Antibodies)/XBP1 (show XBP1 Antibodies) activation. SEC63 and XBP1 (show XBP1 Antibodies) are required for GPS (show NBEAL2 Antibodies) cleavage and maturation of PC1 (show PCSK1 Antibodies), protecting against polycystic disease.

  2. The pro-carcinogenic growth behavior of hepatocytes with low SEC63 expression in the murine model indicates a potential role for SEC63 in hepatocarcinogenesis in general.

  3. Knockout of the murine Sec63 gene inhibits transport of precursor proteins into the endoplasmic reticulum.

  4. SEC63 gene expression is up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy.

SEC63 Antigen Profile

Protein Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

Gene names and symbols associated with SEC63

  • translocation protein SEC63 homolog (LOC100159107) antibody
  • SEC63 homolog (sec63) antibody
  • SEC63 homolog (S. cerevisiae) (SEC63) antibody
  • SEC63 homolog (S. cerevisiae) (Sec63) antibody
  • SEC63-like (S. cerevisiae) (sec63) antibody
  • SEC63-like (S. cerevisiae) (Sec63) antibody
  • 5730478J10Rik antibody
  • AI649014 antibody
  • AW319215 antibody
  • DNAJC23 antibody
  • ERdj2 antibody
  • PRO2507 antibody
  • SEC63-like antibody
  • SEC63L antibody
  • zgc:92718 antibody

Protein level used designations for SEC63

translocation protein SEC63 homolog , SEC63-like protein

GENE ID SPECIES
100159107 Acyrthosiphon pisum
495416 Xenopus laevis
421774 Gallus gallus
11231 Homo sapiens
475016 Canis lupus familiaris
541040 Bos taurus
100328696 Oryctolagus cuniculus
309858 Rattus norvegicus
436861 Danio rerio
140740 Mus musculus
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