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SECIS Binding Protein 2 (SECISBP2) ELISA Kits

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. Additionally we are shipping SECIS Binding Protein 2 Antibodies (61) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse SECISBP2 SECISBP2 75420  
SECISBP2 79048 Q96T21
SECISBP2 79049 Q9QX72
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Top SECIS Binding Protein 2 ELISA Kits at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 11 to 13 Days
$875.60
Details
Rat
96 Tests Log in to see 11 to 13 Days
$875.60
Details

More ELISA Kits for SECIS Binding Protein 2 Interaction Partners

Mouse (Murine) SECIS Binding Protein 2 (SECISBP2) interaction partners

  1. Secisbp2 is essential for embryonic development and enhances selenoprotein expression.

  2. SBP2/SECIS complex activates eEFSec by directing functional interactions between Domain IV and the ribosome to promote Sec-tRNA(Sec) binding and accommodation into the ribosomal A-site

  3. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes.

Fruit Fly (Drosophila melanogaster) SECIS Binding Protein 2 (SECISBP2) interaction partners

  1. Swapping only five amino acids between dSBP2 and human SBP2 in the K-rich domain conferred reversed SECIS-binding properties to the proteins, thus unveiling an important sequence for form 1 binding.

Human SECIS Binding Protein 2 (SECISBP2) interaction partners

  1. SBP2 makes direct contacts with a discrete region of the human 28S rRNA.

  2. The patient showed typical symptoms of SBP2 deficiency, and novel compound heterozygous mutations were identified in SBP2 (p.M515fsX563/p.Q79X).

  3. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes.

  4. Describe subjects with compound heterozygous defects in the SECISBP2 gene. These individuals have reduced synthesis of most of the 25 known human selenoproteins, resulting in a complex phenotype.

  5. Results demonstrate that SECIS-binding protein 2 is required for protection against reactive oxygen species-induced cellular damage and cell survival.

  6. In addition to identifying key amino acids for SECIS recognition by SBP2, our findings led to the proposal that some of the recognition principles governing the 15.5 kD-U4 snRNA interaction must be similar in the SBP2-SECIS RNA complex

  7. Oxidative stress induces nuclear accumulation of SBP2 via oxidation of cysteine residues within a redox-sensitive cysteine-rich domain.

  8. Data suggest that SBP2 is a major determinant in dictating the hierarchy of selenoprotein synthesis via differential selenoprotein mRNA translation and sensitivity to nonsense-mediated decay.

  9. SECIS binding induces a conformational change in SBP2 that recruits eEFSec, which in concert with the Sec incorporation domain gains access to the ribosomal A site

  10. A report of a complex splicing pattern in the 5'-region of human SECISBP2, wherein at least eight splice variants encode five isoforms with varying N-terminal sequence.

SECIS Binding Protein 2 (SECISBP2) Antigen Profile

Antigen Summary

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.

Gene names and symbols associated with SECISBP2

  • SECIS binding protein 2 (Secisbp2) antibody
  • SECIS-binding protein 2 (Sbp2) antibody
  • SECIS binding protein 2 (SECISBP2) antibody
  • SECIS binding protein 2 (secisbp2) antibody
  • 2210413N07Rik antibody
  • 2810012K13Rik antibody
  • CG7066 antibody
  • DKFZp459F1026 antibody
  • Dmel\\CG7066 antibody
  • Sbp2 antibody

Protein level used designations for SECISBP2

selenocysteine insertion sequence-binding protein 2 , CG7066-PA , SECIS binding protein 2 , Sbp2-PA , selenocysteine insertion sequence-binding protein 2-like , SECIS-binding protein 2

GENE ID SPECIES
75420 Mus musculus
38934 Drosophila melanogaster
426815 Gallus gallus
100036714 Xenopus (Silurana) tropicalis
100173231 Pongo abelii
464583 Pan troglodytes
697442 Macaca mulatta
100470097 Ailuropoda melanoleuca
100590393 Nomascus leucogenys
79048 Homo sapiens
476351 Canis lupus familiaris
100153797 Sus scrofa
511202 Bos taurus
79049 Rattus norvegicus
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