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The protein encoded by SERTAD3 was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. Additionally we are shipping SERTAD3 Antibodies (10) and many more products for this protein.
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Transduction of stably expressed human SERTAD3 induces cell transformation in vitro and tumor formation in mice via a transcription factor E2F-dependent mechanism.
The protein encoded by this gene was identified in a yeast two-hybrid assay employing the second subunit of human replication protein A as bait. It is localized to the nucleus and its expression is significantly higher in cancer cell lines compared to normal cell lines. This protein has also been shown to be a strong transcriptional co-activator. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified.
, SERTA domain-containing protein 3
, replication protein-binding trans-activator
, replication protein binding trans-activator