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SETBP1 encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. Additionally we are shipping SETBP1 Antibodies (28) and many more products for this protein.
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AML (show RUNX1 Proteins) with RUNX1 (show RUNX1 Proteins)/RUNX1T1 (show RUNX1T1 Proteins) rearrangement displayed c.2903C>T alteration in the mutational hotspot of SETBP1.
Data describe a new recurrent chromosome translocation, t(12;18)(q14-q15;q12-21), in lipomas and osteochondrolipoma resulting in HMGA2-SETBP1 fusion which suggest a close developmental relationship between the two tumor types.
we described a patient not fulfilling the clinical criteria and showing mutation in SETBP1, we suggest that the facial gestalt associated with neurological involvement would be sufficient to indicate molecular analysis of this particular gene.
Correlation of myelodysplastic syndromes with i(17)(q10 (show EIF2C2 Proteins)) and TP53 (show TP53 Proteins) and SETBP1 mutations.
The SETBP1 and ASXL1 (show ASXL1 Proteins) mutations have pathogenetic roles in CSF3R (show CSF3R Proteins)-mutated chronic neutrophilic leukemia.
SETBP1 mutation might not be involved in the leukemogenisis of acute lymphoblastic leukemia
SETBP1 mutations are critical drivers of ASXL1 (show ASXL1 Proteins)-mutated myelodysplastic syndrome.
mutation analysis of CSF3R (show CSF3R Proteins), SETBP1 and CALR (show CALR Proteins) should be included in the diagnostic criteria for chronic neutrophilic leukemia
Low frequency of SETBP1 mutations have been found in 106 patients with therapy-related myeloid neoplasms.
Mutations in SETBP1 are associated with juvenile myelomonocytic leukemia.
Setbp1 overexpression also causes transcriptional repression of critical hematopoiesis regulator gene Runx1 (show RUNX1 Proteins)
Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 (show HOXA9 Proteins) and Hoxa10 (show HOXA10 Proteins).
This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
A20-binding inhibitor of NF-kappaB activation 2
, SET binding protein 1
, SET-binding protein-like
, SET-binding protein