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Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. Additionally we are shipping SETD7 Proteins (11) and SETD7 Kits (5) and many more products for this protein.
Showing 10 out of 93 products:
Human Polyclonal SETD7 Primary Antibody for EIA, IHC (p) - ABIN356694
Wysocka, Myers, Laherty, Eisenman, Herr: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. in Genes & development 2003
Show all 5 references for ABIN356694
Human Polyclonal SETD7 Primary Antibody for EIA, WB - ABIN356695
Xiao, Jing, Wilson, Walker, Vasisht, Kelly, Howell, Taylor, Blackburn, Gamblin: Structure and catalytic mechanism of the human histone methyltransferase SET7/9. in Nature 2003
Show all 5 references for ABIN356695
Human Polyclonal SETD7 Primary Antibody for IHC (p), WB - ABIN387997
Kwon, Chang, Kwak, Lee, Joachimiak, Kim, Lee, Cho: Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. in The EMBO journal 2003
Show all 4 references for ABIN387997
Human Polyclonal SETD7 Primary Antibody for WB - ABIN2783571
Subramanian, Jia, Kapoor-Vazirani, Powell, Collins, Sharma, Peng, Cheng, Vertino: Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. in Molecular cell 2008
Human Polyclonal SETD7 Primary Antibody for ChIP, IHC (p) - ABIN252611
Narayanan, Ruyechan, Kristie: The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection. in Proceedings of the National Academy of Sciences of the United States of America 2007
Human Monoclonal SETD7 Primary Antibody for EIA, IHC (p) - ABIN121150
Nishioka, Chuikov, Sarma, Erdjument-Bromage, Allis, Tempst, Reinberg: Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. in Genes & development 2002
High SET7 expression is associated with breast cancer.
SET7 was required for GATA1 (show GATA1 Antibodies)-induced breast tumor angiogenesis and growth in nude mice. GATA1 (show GATA1 Antibodies) and SET7 are independent poor prognostic factors in breast cancer.
SET7/SET9-mediated YY1 (show YY1 Antibodies) methylation was shown to be involved in YY1 (show YY1 Antibodies)-regulated gene transcription and cell proliferation.
These results demonstrate that S...O chalcogen bonds contribute to AdoMet (show MAT1A Antibodies) recognition and can enable methyltransferases to distinguish between substrate and product.
Reduced expression of SET7 is associated with gastric cancer progression.
study identified a novel locus associated with serum lycopene concentrations and results raise a number of possibilities regarding the nature of the relationship between SETD7 and lycopene, both independently associated with prostate cancer.
Lysine methylation by SETD7 is important for the fine-tuning of reactive oxygen species signaling through its regulation on pro-inflammatory responses.
Knock-down of SETD7 causes differentiation defects in human embryonic stem cell including delay in both the silencing of pluripotency-related genes and the induction of differentiation genes.
Unleashed expression of Mdm2 (show MDM2 Antibodies) in cancer patients with diminished expression of Set7/9 is associated with poor survival outcome.
Based on our results miR (show MLXIP Antibodies)-153 inhibits proliferation and suppresses EMT (show ITK Antibodies) and the invasive potential of ovarian cancer cells through downregulation of SET7 and ZEB2 (show ZEB2 Antibodies), supporting the pursuit of miR (show MLXIP Antibodies)-153 as a potential target for ovarian cancer intervention.
SETD7 is required for Wnt (show WNT2 Antibodies)-driven intestinal tumorigenesis and regeneration. SETD7-dependent methylation of YAP (show YAP1 Antibodies) facilitates Wnt (show WNT2 Antibodies)-induced nuclear accumulation of beta-catenin (show CTNNB1 Antibodies).
SET7/9 regulates Nos2 expression through methylation of H3K4 in beta cells.
Data indicate that the ability of transcription factor Pdx1 (show PDX1 Antibodies) to regulate genes in beta cells is partially dependent upon its methylation by methyltransferase Set7/9.
study found that Set7 is a modifier of the Hippo pathway. Mice that lack Set7 have a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein target genes.
The response to hyperglycemia in vascular endothelial cells involves Set7 mediated changes in chromatin remodeling and gene expression.
Set7/9-mediated methylation of p53 (show TP53 Antibodies) does not represent a major regulatory event and does not appreciably control p53 (show TP53 Antibodies) activity in vivo.
Set7/9 is dispensable for p53 (show TP53 Antibodies) function in the mouse.
Define a biological function for Set7 in muscle differentiation and provide a molecular mechanism by which Set7 modulates myogenic transcription factors during muscle differentiation.
Pdx1 (show PDX1 Antibodies)-dependent Set7/9 expression may be crucial to enhancing chromatin accessibility and transcription of beta-cell genes.
Methylation of p53 (show TP53 Antibodies) by Set7 mediates p53 (show TP53 Antibodies) acetylation and activity in vivo.
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the -K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
, SET domain-containing protein 7
, histone H3-K4 methyltransferase SETD7
, histone H3-lysine 4-specific methyltransferase
, histone-lysine N-methyltransferase SETD7
, lysine N-methyltransferase 7
, H3-K4 methyltransferase