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SET Domain Containing (Lysine Methyltransferase) 8 Proteins (SETD8)

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Additionally we are shipping SETD8 Antibodies (105) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SETD8 387893 Q9NQR1
SETD8 67956 Q2YDW7
SETD8 532622 Q2YDJ8
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Top SETD8 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 16 Days
$382.80
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,907.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,959.00
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$3,197.33
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 1 to 2 Days
$455.00
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 1 to 2 Days
$455.00
Details

SETD8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

Cow (Bovine)

Top referenced SETD8 Proteins

  1. Human SETD8 Protein expressed in Escherichia coli (E. coli) - ABIN2004726 : Nishioka, Rice, Sarma, Erdjument-Bromage, Werner, Wang, Chuikov, Valenzuela, Tempst, Steward, Lis, Allis, Reinberg: PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. in Molecular cell 2002 (PubMed)
    Show all 4 references for ABIN2004726

More Proteins for SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) Interaction Partners

Human SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) interaction partners

  1. SET8 expression is associated with overall survival in gastric cancer

  2. analysis of a structural model for how Set8 uses multivalent interactions to bind and methylate the nucleosome based on crystallographic and solution studies of the Set8/nucleosome complex

  3. This study showed SCF (show KITLG Proteins)(beta-TRCP (show BTRC Proteins)) earmarks Set8 for ubiquitination and degradation in a casein kinase I (show CSNK1D Proteins)-dependent manner, which is activated by DNA-damaging agents.

  4. Overall, the results revealed that miR (show MLXIP Proteins)-127-3p acts as a tumor suppressor and that its down-regulation in cancer may contribute to OS progression and metastasis.

  5. commonality of SPS8I1-3 against SETD8, together with their distinct structures and mechanisms for SETD8 inhibition, argues for the collective application of these compounds as SETD8 inhibitors

  6. SET8 is required for 53BP1 (show TP53BP1 Proteins) recruitment and efficient repair of DSB.

  7. These data suggest that there are significant associations between the miR (show MLXIP Proteins)-502-binding site single nucleotide polymorphism in the 3'-UTR of SET8 and the TP53 (show TP53 Proteins) codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction.

  8. Our results demonstrated that SETD8 rs16917496 C/T polymorphism was associated with decreased risk of developing pediatric acute lymphoblastic leukemia

  9. The SNP in the miR502 binding site of the SET8 3'-untranslated region seems to influence survival of non-Hodgkin's lymphoma.

  10. significant association between the polymorphism (rs16917496) of the miR (show MLXIP Proteins)-502-binding site in the 3'-UTR of SET8 and TP53 (show TP53 Proteins) codon 72 polymorphism and the risk of developing NSCLC.

Mouse (Murine) SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) interaction partners

  1. PR-Set7 is a direct target of Cul4A (show CUL4A Proteins) for degradation and involved in the formation of lung tumors in the conditional Cul4A (show CUL4A Proteins) transgenic mouse model.

  2. These results suggest that Setd8 is an important regulator of erythroid maturation that works in part through repression of Gata2 (show GATA2 Proteins) expression.

  3. These results establish SetD8 as a determinant of erythroid cell maturation and provide a framework for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GATA factor function.

  4. all of the H3K36-specific methyltransferases, including ASH1L (show ASH1L Proteins), HYPB, NSD1, and NSD2 (show WHSC1 Proteins) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Proteins), and Pr-Set7 were not affected by ubH2A.

  5. Data indicate a vital link between GATA-1 (show GATA1 Proteins) and the histone H4 lysine 20 methyltransferase PR-Set7/SetD8 (SetD8).

  6. Pr-set7 knockdown caused increased gammaH2AX (show H2AFX Proteins) foci on chromosomes indicating DNA damage on chromosomes.

  7. Setd8 is a crucial inhibitor of apoptosis in skin and its activity is essential for epidermal stem cell survival, proliferation and differentiation

  8. the SET8 and PCNA (show PCNA Proteins) interaction couples H4-K20 (show KRT20 Proteins) methylation with DNA replication

  9. PR-Set7 enzymatic activity is essential for mammalian cell cycle progression and for the maintenance of genomic stability, most likely by monomethylating histone H4K20.

  10. Cell cycle analysis after synchronization indicated that defects at the S and G(2)/M phases were a consequence of decreased H4K20me1 due to the absence of PR-Set7.

SETD8 Protein Profile

Protein Summary

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).

Gene names and symbols associated with SETD8

  • SET domain containing (lysine methyltransferase) 8 (SETD8)
  • SET domain containing (lysine methyltransferase) 8 (Setd8)
  • 2410195B05Rik protein
  • AA617402 protein
  • AW536475 protein
  • KMT5A protein
  • PR-SET7 protein
  • SET07 protein
  • SET8 protein

Protein level used designations for SETD8

H4-K20-HMTase SETD8 , H4-K20-specific histone methyltransferase , H4K20-specific histone methyltransferase splice variant Set8b , N-lysine methyltransferase SETD8 , PR/SET domain containing protein 8 , PR/SET domain-containing protein 07 , PR/SET07 , SET domain-containing protein 8 , histone-lysine N-methyltransferase SETD8 , lysine N-methyltransferase 5A , PR-Set7 , SET domain-containing 8

GENE ID SPECIES
387893 Homo sapiens
67956 Mus musculus
532622 Bos taurus
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