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By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SH2D1B Proteins (5) and many more products for this protein.
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Human Polyclonal SH2D1B Primary Antibody for FACS, IHC (p) - ABIN653070
Morra, Howie, Grande, Sayos, Wang, Wu, Engel, Terhorst: X-linked lymphoproliferative disease: a progressive immunodeficiency. in Annual review of immunology 2001
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Human Polyclonal SH2D1B Primary Antibody for EIA, FACS - ABIN954786
Tangye, van de Weerdt, Avery, Hodgkin: CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. in European journal of immunology 2002
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Human Polyclonal SH2D1B Primary Antibody for ELISA, WB - ABIN335133
Clarkson, Simmonds, Puklavec, Brown: Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase. in The Journal of biological chemistry 2007
Data indicate that Ewing's sarcoma-associated transcript-2 (EAT-2) over-expression increased the anti-tumor activity of NK cells against K562 tumor cell. targets.
EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 Antibodies) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 Antibodies) kinase.
NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2
EAT-2 negatively regulates cytokine production in dendritic cells downstream of SLAM (show SLAMF1 Antibodies) engagement and a genetic polymorphism that disturbs this process promotes the development of lupus.
EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule (show SLAMF1 Antibodies) family receptor-specific NK cell functions in C57BL/6 mice.
Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src (show SRC Antibodies) kinases to SLAM (show SLAMF1 Antibodies) family receptors using a mechanism that is distinct from that of SAP (show APCS Antibodies).
EAT-2 mediates CRACC (show SLAMF7 Antibodies) function. In the absence of EAT-2, CRACC (show SLAMF7 Antibodies) inhibited natural killer cell function.
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001
SH2 domain protein 1B1
, SH2 domain containing 1B
, SH2 domain-containing protein 1B
, EWS/FLI1-activated transcript 2
, SH2 domain-containing molecule EAT2
, EWS/FLI1 activated transcript 2