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anti-SH2 Domain Containing 1B (SH2D1B) Antibodies

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008].. Additionally we are shipping SH2D1B Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SH2D1B 501869  
SH2D1B 117157 O14796
SH2D1B 26904  
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Top anti-SH2D1B Antibodies at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of SH2D1B Antibody (Center) (ABIN653070) in Jurkat cell line lysates (35 µg/lane). SH2D1B (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with SH2D1B Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB Flow Cytometry analysis of Jurkat cells using SH2D1B Antibody (Center) Cat.-No AP53896PU-N (Bottom histogram) compared to a negative control cell (Top histogram). FITC-conjugated Goat-anti-Rabbit secondary antibodies were used for the analysis. Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human lung carcinoma reacted with SH2D1B Antibody (Center) Cat.-No AP53896PU-N which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using SH2D1B Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IHC, ELISA 100 μg Log in to see 11 to 16 Days
$412.86
Details
Mouse Goat Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$419.83
Details
Human Mouse Un-conjugated IP, ELISA Detection limit for recombinant GST tagged SH2D1B is 0.3 ng/ml as a capture antibody. Immunoprecipitation of SH2D1B transfected lysate using anti-SH2D1B monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with SH2D1B MaxPab rabbit polyclonal antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 8 to 10 Days
$595.83
Details

SH2D1B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human , ,
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Mouse (Murine) ,
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Top referenced anti-SH2D1B Antibodies

  1. Human Polyclonal SH2D1B Primary Antibody for FACS, IHC (p) - ABIN653070 : Morra, Howie, Grande, Sayos, Wang, Wu, Engel, Terhorst: X-linked lymphoproliferative disease: a progressive immunodeficiency. in Annual review of immunology 2001 (PubMed)
    Show all 2 references for ABIN653070

  2. Human Polyclonal SH2D1B Primary Antibody for EIA, FACS - ABIN954786 : Tangye, van de Weerdt, Avery, Hodgkin: CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2. in European journal of immunology 2002 (PubMed)
    Show all 2 references for ABIN954786

  3. Human Polyclonal SH2D1B Primary Antibody for ELISA, WB - ABIN335133 : Clarkson, Simmonds, Puklavec, Brown: Direct and indirect interactions of the cytoplasmic region of CD244 (2B4) in mice and humans with FYN kinase. in The Journal of biological chemistry 2007 (PubMed)

More Antibodies against SH2D1B Interaction Partners

Human SH2 Domain Containing 1B (SH2D1B) interaction partners

  1. Data indicate that Ewing's sarcoma-associated transcript-2 (EAT-2) over-expression increased the anti-tumor activity of NK cells against K562 tumor cell. targets.

  2. EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 Antibodies) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 Antibodies) kinase.

  3. NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2

Mouse (Murine) SH2 Domain Containing 1B (SH2D1B) interaction partners

  1. EAT-2 negatively regulates cytokine production in dendritic cells downstream of SLAM (show SLAMF1 Antibodies) engagement and a genetic polymorphism that disturbs this process promotes the development of lupus.

  2. EAT-2 mediates its effects in natural killer cells by linking SLAM (show SLAMF1 Antibodies) family receptors to phospholipase Cgamma, calcium fluxes, and Erk (show EPHB2 Antibodies) kinase.

  3. EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule (show SLAMF1 Antibodies) family receptor-specific NK cell functions in C57BL/6 mice.

  4. Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src (show SRC Antibodies) kinases to SLAM (show SLAMF1 Antibodies) family receptors using a mechanism that is distinct from that of SAP (show APCS Antibodies).

  5. EAT-2 mediates CRACC (show SLAMF7 Antibodies) function. In the absence of EAT-2, CRACC (show SLAMF7 Antibodies) inhibited natural killer cell function.

SH2D1B Antigen Profile

Protein Summary

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001

Gene names and symbols associated with SH2D1B

  • SH2 domain containing 1B (Sh2d1b) antibody
  • SH2 domain containing 1B (SH2D1B) antibody
  • SH2 domain protein 1B1 (Sh2d1b1) antibody
  • EAT-2 antibody
  • EAT-2A antibody
  • Eat2 antibody
  • Eat2a antibody
  • RGD1563935 antibody
  • Sh2d1b antibody
  • Sh2d1b1 antibody

Protein level used designations for SH2D1B

SH2 domain protein 1B1 , SH2 domain containing 1B , SH2 domain-containing protein 1B , EAT-2 , EWS/FLI1-activated transcript 2 , SH2 domain-containing molecule EAT2 , EWS/FLI1 activated transcript 2

GENE ID SPECIES
501869 Rattus norvegicus
418411 Gallus gallus
457464 Pan troglodytes
609474 Canis lupus familiaris
617485 Bos taurus
720097 Macaca mulatta
117157 Homo sapiens
26904 Mus musculus
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