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The protein encoded by SIX6 is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. Additionally we are shipping SIX Homeobox 6 Proteins (5) and SIX Homeobox 6 Kits (1) and many more products for this protein.
Showing 10 out of 34 products:
Chicken Polyclonal SIX6 Primary Antibody for IHC, WB - ABIN2779603
Aijaz, Clark, Williamson, van Heyningen, Morrison, Fitzpatrick, Collin, Ragge, Christoforou, Brown, Hanson: Absence of SIX6 mutations in microphthalmia, anophthalmia, and coloboma. in Investigative ophthalmology & visual science 2004
Human Polyclonal SIX6 Primary Antibody for IF, ELISA - ABIN1533566
Gallardo, Lopez-Rios, Fernaud-Espinosa, Granadino, Sanz, Ramos, Ayuso, Seller, Brunner, Bovolenta, Rodríguez de Córdoba et al.: Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary ... in Genomics 1999
SIX3 and SIX6 play distinct but compensatory roles in regulating transcription of gonadotrope-specific genes as gonadotrope cells differentiate.
Six6-null mice display abnormal patterns of circadian behavior.
SoxB1 transcription factors are direct activators of Six6 expression in the ventral forebrain
Six6 plays an important role in the regulation of GnRH expression and hypothalamic control of fertility.
in association with Dach (show DACH1 Antibodies) corepressors, regulates proliferation of retinal and pituitary precursor cells by directly repressing cyclin-dependent kinase (show CDK1 Antibodies) inhibitors, including the p27Kip1 (show CDKN1B Antibodies) promoter
Six 3 and Six 6 are differentially required during forebrain development; gene expression in brain
Results show that Lhx2 (show LHX2 Antibodies) and Pax6 (show PAX6 Antibodies) transcription factors operate in a concerted manner during retinal development to promote transcriptional activation of the Six6 homeobox (show PRRX1 Antibodies)-gene in primitive and mature retinal progenitors.
Six1 (show SIX1 Antibodies) regulates p53 (show TP53 Antibodies) via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26 (show RPL26 Antibodies).
Single nucleotide polymorphism in SIX6 gene is associated with primary open angle glaucoma.
SIX6 and/or intraocular pressure promotes primary open-angle glaucoma by directly increasing p16INK4a (show CDKN2A Antibodies) expression.
we report a homozygous missense mutation of SIX6 associated with a unique eye phenotype characterized by optic disc anomalies, macular atrophy, and coloboma of the iris and chorioretina.
Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma.
Our results, in combination with previous SIX6 work, lead us to hypothesize that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells.
No evidence was found that SIX6 mutations underlie human congenital structural eye malformations.
Six6 and Six2 (show SIX2 Antibodies) differ in their DNA-binding mechanisms and in the consequences of their interaction with protein tyrosine phosphatase (show ACP1 Antibodies) Eyes Absent in Six2 (show SIX2 Antibodies)/6-DNA-binding ability.
BOR (show EYA1 Antibodies) and OAVS features are associated with duplication of SIX1 (show SIX1 Antibodies), SIX6 and OTX2 (show OTX2 Antibodies) resulting from a complex chromosomal rearrangement.
a new helix in the C-terminal domain of the mutated bovine SIX6 protein was revealed, which possibly affects pituitary development and hormone secretion
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).
homeobox protein SIX6
, optic homeobox 2
, sine oculis homeobox homolog 6
, sine oculis-related homeobox 6 homolog
, sine oculis-related homeobox 6a
, homeobox protein Optx2
, homeodomain protein OPTX2