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Mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Additionally we are shipping SLAM Family Member 7 Proteins (19) and SLAM Family Member 7 Kits (5) and many more products for this protein.
Showing 10 out of 142 products:
Human Monoclonal SLAMF7 Primary Antibody for FACS - ABIN2479977
Yamate, Ransom: Effects of altered gliogenesis on activity-dependent K+ accumulation in the developing rat optic nerve. in Brain research 1985
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Human Monoclonal SLAMF7 Primary Antibody for FACS - ABIN2479981
Bouchon, Cella, Grierson, Cohen, Colonna: Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 3 Pubmed References
Human Monoclonal SLAMF7 Primary Antibody for FACS, IP - ABIN2479975
Tassi, Colonna: The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. in Journal of immunology (Baltimore, Md. : 1950) 2005
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Human Monoclonal SLAMF7 Primary Antibody for FACS - ABIN4897032
Lisenko, Schönland, Jauch, Andrulis, Röcken, Ho, Goldschmidt, Hegenbart, Hundemer: Flow cytometry-based characterization of underlying clonal B and plasma cells in patients with light chain amyloidosis. in Cancer medicine 2016
Human Monoclonal SLAMF7 Primary Antibody for FACS - ABIN4897035
Tai, Dillon, Song, Leiba, Li, Burger, Lee, Podar, Hideshima, Rice, van Abbema, Jesaitis, Caras, Law, Weller, Xie, Richardson, Munshi, Mathiot, Avet-Loiseau, Afar, Anderson: Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu. in Blood 2008
Human Polyclonal SLAMF7 Primary Antibody for IF (p) - ABIN915407
Maekawa, Osawa, Izumi, Nagao, Takano, Okada, Tachi, Teramoto, Kawamura, Horiuchi, Saga, Kato, Yamamura, Watanabe, Kobayashi, Kobayashi, Sato, Hashimoto, Suzu, Kimura: Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis. in Leukemia 2017
Human Monoclonal SLAMF7 Primary Antibody for CyTOF, FACS - ABIN4900006
Hislop, Palendira, Leese, Arkwright, Rohrlich, Tangye, Gaspar, Lankester, Moretta, Rickinson: Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets. in Blood 2010
The SLAMF-AS2 (show ARSA Antibodies) isoforms are expressed the lowest levels among the three transcripts in both normal and infected mammary tissues.
Memory CD8 (show CD8A Antibodies)+ T cells from SLE patients displayed decreased amounts of SLAMF7, a surface receptor that characterizes effector CD8 (show CD8A Antibodies)+ T cells. Ligation of SLAMF7 increased CD8 (show CD8A Antibodies)+ T cell degranulation capacity and the percentage of IFNgamma-producing cells in response to antigen challenge in SLE patients and healthy controls. SLAMF7 engagement promoted cytotoxic lysis of target cells in response to stimulation with viral antig...
phagocytosis of haematopoietic tumour cells during SIRPalpha-CD47 (show CD47 Antibodies) blockade was strictly dependent on SLAM (show SLAMF1 Antibodies) family receptors in vitro and in vivo; in both mouse and human cells, this function required a single SLAM (show SLAMF1 Antibodies) family member, SLAMF7 (also known as CRACC, CS1 (show CSH1 Antibodies), CD319), expressed on macrophages and tumour cell targets
Blimp-1 (show PRDM1 Antibodies) regulates the transcription of CS1 (show CSH1 Antibodies) gene in NK and B cell lines from multiple myeloma and diffuse large B cell lymphoma patients.
SLAMF7-triggered inhibition is mediated by a mechanism involving Src (show SRC Antibodies) kinases, CD45 (show PTPRC Antibodies), and SHIP-1 (show INPP5D Antibodies) that is defective in MM cells
Our data highlight the therapeutic potential of targeting CD319 in rheumatoid arthritis
SLAMF7 plays an inhibitory role in human monocytes to control proinflammatory immune responses.
These results suggest a role for CD319 and CD229 (show LY9 Antibodies) in the systemic lupus erythematosus disease process.
These data suggest an involvement of CRACC-mediated NK cell activation in periodontal tissue destruction and point to a plausible distinction in the pathobiology of aggressive and chronic periodontitis.
altered expression of splice variants of CS1 (show CSH1 Antibodies) and 2B4 (show CD244 Antibodies) that mediate differential signalling in PBMC from patients with SLE.
Data show that pair-wise ligations of 2B4 (show CD244 Antibodies) with DNAM-1 (show CD226 Antibodies) and/or NKG2D (show KLRK1 Antibodies) lead to increased effector functions of primary CD4 (show CD4 Antibodies)(+)CD28 (show CD28 Antibodies)(-) T cells to suboptimal levels of anti-CD3 (show CD3 Antibodies) stimulation.
phagocytosis of haematopoietic tumour cells during SIRPalpha-CD47 (show CD47 Antibodies) blockade was strictly dependent on SLAM (show SLAMF1 Antibodies) family receptors in vitro and in vivo; in both mouse and human cells, this function required a single SLAM (show SLAMF1 Antibodies) family member, SLAMF7 (also known as CRACC, CS1, CD319), expressed on macrophages and tumour cell targets
CRACC-CRACC interaction between Kupffer and NK cells contributes to poly I:C/D-GalN (show GAL Antibodies) induced hepatitis.
2B4 (show CD244 Antibodies), NTB-A (show SLAMF6 Antibodies) and CRACC have roles in the regulation of Natural Killer cell function [review]
CRACC was a critical positive regulator of NK cell function mediated by EAT-2.
Mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion (By similarity).
SLAM family member 7
, SLAM family member 7 variant 1
, SLAM family member 7 variant 2
, 19A24 protein
, CD2 subset 1
, CD2-like receptor activating cytotoxic cells
, CD2-like receptor-activating cytotoxic cells
, membrane protein FOAP-12
, novel LY9 (lymphocyte antigen 9) like protein
, protein 19A
, leukocyte cell-surface antigen
, novel Ly9