SMAD, Mothers Against DPP Homolog 5 Proteins (SMAD5)

The protein encoded by SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. Additionally we are shipping SMAD5 Antibodies (107) and SMAD5 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SMAD5 4090 Q99717
SMAD5 17129 P97454
SMAD5 59328 Q9R1V3
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Top SMAD5 Proteins at

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Mouse GST tag,His tag 100 μg Log in to see 20 to 21 Days
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Pongo abelii His tag   1 mg Log in to see 60 to 71 Days
Yeast Zebrafish His tag   1 mg Log in to see 60 to 71 Days
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days

SMAD5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
Rat (Rattus)

Top referenced SMAD5 Proteins

  1. Mouse (Murine) SMAD5 Protein expressed in Baculovirus infected Insect Cells - ABIN2008249 : Riggins, Thiagalingam, Rozenblum, Weinstein, Kern, Hamilton, Willson, Markowitz, Kinzler, Vogelstein: Mad-related genes in the human. in Nature genetics 1996 (PubMed)

More Proteins for SMAD, Mothers Against DPP Homolog 5 (SMAD5) Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.

  2. Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.

  3. Data show that interplay of Smad1 (show SMAD1 Proteins)/5 and MAP kinase (show MAPK1 Proteins) signaling system (ERK (show MAPK1 Proteins) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.

  4. this study uncovers that smad1 (show SMAD1 Proteins) and smad9 (show SMAD9 Proteins) act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.

  5. Functional investigation of a subset of these genes, fgf10a (show FGF10 Proteins), tgfb2 (show TGFB2 Proteins), pax9 (show PAX9 Proteins), and smad5 revealed their necessity in zebrafish palatogenesis.

  6. maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2 (show BMP4 Proteins)/7 signaling to establish the initial dorsoventral asymmetry

  7. Data show that patterning of the eye primordia in Smad5-deficient embryos starts during blastula and early gastrula stages.

  8. that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 (show SMAD1 Proteins) and Smad5.

  9. Data show that Smad5 expression is ubiquitous during testis development but becomes cell-specific in the adult.

Human SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. the BMP-2 (show BMP2 Proteins)/Smad1 (show GARS Proteins)/5/RUNX2 (show RUNX2 Proteins) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (show BGLAP Proteins) synth

  2. miR (show MLXIP Proteins)-23a and miR (show MLXIP Proteins)-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL (show FASL Proteins)-Fas (show FAS Proteins) pathway

  3. Our findings suggest that suppression of miR (show MLXIP Proteins)-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 (show RUNX2 Proteins) signaling axis.

  4. Overexpression of the BMP4 (show BMP4 Proteins)/SMAD4 (show SMAD4 Proteins)/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.

  5. The polycomb group protein L3MBTL1 (show L3MBTL1 Proteins) represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.

  6. adult human Sertoli cells assumed similar morphological features, stable global gene expression profiles and numerous proteins, and activation of AKT (show AKT1 Proteins) and SMAD1 (show GARS Proteins)/5 during long-period culture.

  7. balance between Smad1 (show GARS Proteins)/5- and Smad2 (show SMAD2 Proteins)/3-dependent signaling defines the outcome of the effect of TGF-beta (show TGFB1 Proteins) on atherosclerosis where Smad1 (show GARS Proteins)/5 is responsible for proatherogenic effects

  8. among the 15 SNPs, rs3206634 was significantly associated with KD in a recessive model (odds ratio = 2.31, p = 0.019), whereas there was no association between any of the 15 SNPs and CALs (show CA8 Proteins).

  9. Our results indicated that KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4 (show SMAD4 Proteins)/smad5 pathway.

  10. Inhibiting Smurf1 (show SMURF1 Proteins) mediated ubiquitination of Smad1 (show GARS Proteins)/5.

Mouse (Murine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. Smad1 (show SMAD1 Proteins) and Smad5 have overlapping functions to govern hepcidin (show HAMP Proteins) transcription. Moreover, erythropoietin (show EPO Proteins) and erythroferrone target Smad1 (show SMAD1 Proteins)/5 signaling and require Smad1 (show SMAD1 Proteins)/5 to suppress hepcidin (show HAMP Proteins) expression.

  2. miR (show MLXIP Proteins)-106b-5p and miR-17-5p are novel Smad5 regulators.

  3. BetA can enhance in vivo osteogenic potentials of BMP2 (show BMP2 Proteins), possibly via stimulating Smad 1 (show SMAD1 Proteins)/5/8 and p38 (show CRK Proteins) pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.

  4. Data show that in R-Smad (show SMAD1 Proteins) proteins Smad1 (show SMAD1 Proteins);Smad5 knockout embryonic stem cells (mESCs), the bone morphogenetic proteins (BMP)-SMAD (show SMAD1 Proteins) signaling is dispensable for self-renewal.

  5. Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).

  6. The crystal structure of Smad5-MH1 (show SCN5A Proteins) domain in complex with a composite DNA sequence demonstrates that the MH1 (show SCN5A Proteins) domain is targeted to a binding site with modular binding modes, and the length of the DNA spacer affects the MH1 (show SCN5A Proteins) assembly.

  7. The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2 (show BMP2 Proteins)/Smad1 (show SMAD1 Proteins)/5/8 and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathways.

  8. FLI1 (show FLI1 Proteins) and GATA2 (show GATA2 Proteins) are upstream regulators of SMAD1 (show SMAD1 Proteins) and SMAD5 expression in endothelial cells.

  9. Data indicate that PDGF (show PDGFA Proteins)-AA promotes mesenchymal stem cel migration via bone morphogenetic protein 2 (BMP2 (show BMP2 Proteins))-smad (show SMAD1 Proteins) proteins smad1 (show SMAD1 Proteins)/5/8 activation requires lysosome-mediated degradation of PDGF (show PDGFA Proteins) alpha Receptor (PDGFRalpha).

  10. some pSMAD1/5 targets, like Gata3 (show GATA3 Proteins), function specifically in transit amplifying cell lineage-progression.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. a detailed computational model for TGF-beta (show TGFB1 Proteins) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).

SMAD5 Protein Profile

Protein Summary

The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with SMAD5

  • SMAD family member 5 (SMAD5)
  • MAD homolog 5 (Drosophila) (smad5)
  • SMAD family member 4, gene 2 (smad4.2-b)
  • SMAD family member 5 (Smad5)
  • 1110051M15Rik protein
  • AI451355 protein
  • DKFZp468M0619 protein
  • dpc4 protein
  • Dwf-C protein
  • DWFC protein
  • fb67b04 protein
  • jip protein
  • JV5-1 protein
  • mad protein
  • madh4 protein
  • Madh5 protein
  • MusMLP protein
  • sb:cb400 protein
  • SBN protein
  • SMAD5 protein
  • smad10 protein
  • smd5 protein
  • wu:fb67b04 protein
  • xsmad4 protein
  • XSmad4alpha protein

Protein level used designations for SMAD5

mothers against decapentaplegic homolog 5 , SMA- and MAD-related protein 5 , SMAD 5 , SMAD family member 5 , mothers against DPP homolog 5 , pgy , piggytail , somitabun , MAD, mothers against decapentaplegic homolog 5 , SMAD, mothers against DPP homolog 5 , mothers against decapentaplegic, drosophila, homolog of, 5 , MAD homolog 5 , Smad 5 , dwarfin-C , mSmad5 , Mothers against decapentaplegic homolog 5

100033851 Equus caballus
30641 Danio rerio
403398 Xenopus laevis
4090 Homo sapiens
17129 Mus musculus
59328 Rattus norvegicus
395679 Gallus gallus
481520 Canis lupus familiaris
768050 Bos taurus
100173534 Pongo abelii
100303615 Sus scrofa
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