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Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
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Data indicate that kinetochore protein Spc24 (SPC24) may be a promising molecular target for hepatocellular carcinoma (HCC (show FAM126A Proteins)) therapy.
hSPC24 is a component of the human NDC80 (show NDC80 Proteins) kinetochore complex
the Spc24, Spc25 (show SPC25 Proteins), Nuf2 (show NUF2 Proteins), and Ndc80/Hec1 (show NDC80 Proteins) complex is a faithful copy of the endogenous Ndc80 (show NDC80 Proteins) complex
Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (By similarity).
SPC24, NDC80 kinetochore complex component, homolog
, kinetochore protein Spc24
, spindle pole body component 24 homolog