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SPO11 Meiotic Protein Covalently Bound To DSB Homolog (S. Cerevisiae) Proteins (SPO11)

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. Additionally we are shipping SPO11 Antibodies (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SPO11 23626 Q9Y5K1
Rat SPO11 SPO11 366261  
SPO11 26972 Q9WTK8
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Top SPO11 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Caenorhabditis elegans His tag   1 mg Log in to see 56 to 66 Days
$3,184.50
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SPO11 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for SPO11 Meiotic Protein Covalently Bound To DSB Homolog (S. Cerevisiae) (SPO11) Interaction Partners

Human SPO11 Meiotic Protein Covalently Bound To DSB Homolog (S. Cerevisiae) (SPO11) interaction partners

  1. Data suggest that the combined genotypes of glutathionine S-transferase GSTM1 (-/-), GSTT1 (+/+), GSTP1 (AA) and meiotic recombination protein SPO11 (CT) may be associated with idiopathic male infertility in ethnic Han Chinese.

  2. Polymorphisms within the SPO11 gene are linked to the susceptibility of azoospermia and oligozoospermia male infertility.

  3. SPO11 might has an effect on premorbid functioning, which increase susceptibility for idiopathic male reproduction

  4. Mutations in the human SPO11 gene are not common causes of infertility in man

  5. Data show that there is no association between SPO11 gene mutation and premature ovarian failure.

Mouse (Murine) SPO11 Meiotic Protein Covalently Bound To DSB Homolog (S. Cerevisiae) (SPO11) interaction partners

  1. suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele

  2. our results indicate that in addition to asynapsis, persistent SPO11-induced DSBs are important for the initiation of MSCI and MSUC, and that SPO11-independent DNA repair foci contribute to the MSUC response in oocytes.

  3. Mice with greater or fewer copies of the Spo11 gene--with correspondingly greater or fewer numbers of early recombination foci--exhibited relatively invariant crossover numbers.

  4. chromosome synapsis defects and sexually dimorphic meiotic progression in Spo11 deficient mice

  5. Spo11 is not required for Ig hypermutation or class switch recombination

  6. In Spo11 -/- cells, SMC1 (show SMC1A Proteins) localization on meiotic chromosomes is mainly associated with homologous or non-homologous synapsed regions, whereas SMC3 (show SMC3 Proteins) localized throughout the chromosomes. Both localized along chromosome cores of Spo11 null spermatocytes.

  7. meiotic double-stranded breaks are processed by endonucleolytic cleavage that releases Spo11 attached to an oligonucleotide with a free 3'-OH

  8. The presence of these L-foci in Spo11(-/-) spermatocytes raises the interesting possibility of yet uncharacterized alterations in DNA or chromosome structure in Spo11(-/-) cells.

  9. Detection of the release product, SPO11-oligonucleotide complexes, from mouse testis lysates.

SPO11 Protein Profile

Protein Summary

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described.

Gene names and symbols associated with SPO11

  • Protein SPO-11 (spo-11)
  • SPO11 meiotic protein covalently bound to DSB (SPO11)
  • SPO11 meiotic protein covalently bound to DSB (Spo11)
  • SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae) (spo11)
  • SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae) (SPO11)
  • SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae) (Spo11)
  • AI449549 protein
  • CT35 protein
  • SPATA43 protein
  • TOPVIA protein
  • zgc:77876 protein

Protein level used designations for SPO11

SPO11 meiotic protein covalently bound to DSB homolog , cancer/testis antigen 35 , meiotic recombination protein SPO11 , spermatogenesis associated 43 , sporulation protein, meiosis-specific, SPO11 homolog , sporulation protein, meiosis-specific, SPO11 , sporulation protein, meiosis-specific, SPO11 homolog (S. cervisiae)

GENE ID SPECIES
191771 Caenorhabditis elegans
23626 Homo sapiens
366261 Rattus norvegicus
402982 Danio rerio
610247 Canis lupus familiaris
100125974 Sus scrofa
524105 Bos taurus
26972 Mus musculus
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