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SRY (Sex Determining Region Y)-Box 10 Proteins (SOX10)

SOX10 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX10 Antibodies (80) and SOX10 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOX10 6663 P56693
SOX10 29361 O55170
SOX10 20665 Q04888
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Top SOX10 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$3,219.33
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,250.50
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,296.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,312.83
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,322.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

SOX10 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine)

More Proteins for SRY (Sex Determining Region Y)-Box 10 (SOX10) Interaction Partners

Human SRY (Sex Determining Region Y)-Box 10 (SOX10) interaction partners

  1. Despite the fact that the E248fs has a dominant-negative effect on SOX10, its reduced stability may down-regulate the transcription of MITF (show MITF Proteins) and decrease the synthesis of melanin

  2. SOX10-positivity rules out the diagnosis of ependymoma among other glial tumors with high confidence

  3. SOX-10 expression is exclusively specific for all cases of metastatic melanoma.

  4. Our study shows an inversed preferential nuclear expression of SLUG (show SNAI2 Proteins), SOX10, and SOX9 (show SOX9 Proteins) in triple negative and non-triple negative cases.

  5. SOX10 mutations can mimic non-syndromic hearing impairment.

  6. our data imply that the same SOX10 mutations can underlie both typical Waardenburg syndrome and Kallmann Syndrome with deafness without skin/hair hypopigmentation, Hirschsprung disease, or neurological defects

  7. Subnuclear re-localization of SOX10 and p54NRB (show NONO Proteins) correlates with a unique neurological phenotype associated with SOX10 missense mutations.

  8. Our result confirm the thesis that heterozygous deletions at SOX10 is an important pathogenicity for Waardenburg syndrome type II.

  9. The use of SOX10 may increase the diagnostic accuracy of salivary gland oncocytic lesions on fine needle aspiration.

  10. Study shows that by uncoupling the effects of gain-of-function and haploinsufficiency in vivo, the effect of PCWH-causing SOX10 mutation is solely pathogenic in each SOX10-expressing cellular lineage in a dosage-dependent manner.

Xenopus laevis SRY (Sex Determining Region Y)-Box 10 (SOX10) interaction partners

  1. The activity of Sox-10 transcription factor is well conserved and is regulated by SUMOylation.

Mouse (Murine) SRY (Sex Determining Region Y)-Box 10 (SOX10) interaction partners

  1. Kaiso (show ZBTB33 Proteins) and Sox10 sequentially interact with Tcf7l2 (show TCF7L2 Proteins) to coordinate the maturation of oligodendrocyte.

  2. Findings uncover a central role of SOX10 as a global regulator of gene expression in the melanocyte lineage by targeting diverse regulatory pathways.

  3. Ets1 (show ETS1 Proteins) and Sox10 interact to promote proper melanocyte and enteric ganglia development from the neural crest.

  4. Sox10(rtTA/+) driven reporter expression in the cochlea persists for at least 54 days after cessation of neonatal induction

  5. Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice.

  6. Our findings provide proof-of-concept that Sox10 can convert conducive cells into oligodendrocyte-like cells in vivo and delineates options for future therapeutic strategies.

  7. Conditional deletion of the neural crest specific transcription factor, Sox10, using the rhombic lip/neural crest specific Wnt1 (show WNT1 Proteins)-cre driver spares Sox10 expression in the ear.

  8. This is strongly reminiscent of the situation in Schwann cells where Sox10 first induces and then cooperates with Krox20 (show EGR2 Proteins) during myelination

  9. Decreases in Sox10 expression levels and a loss of Sox10(+) cells in both mouse and human aged ears suggests an important role of Sox10 in the maintenance of structural and functional integrity of the lateral wall.

  10. SOX10 continued to be expressed from the developmental stage to adulthood in the acinar and both luminal and abluminal intercalated ducts in the major salivary gland.

Zebrafish SRY (Sex Determining Region Y)-Box 10 (SOX10) interaction partners

  1. Demonstrate a contribution of sox10-dependent cranial neural crest to olfactory sensory neurons in zebrafish and provide important insights into the assembly of the nascent olfactory system.

  2. Data indicate that the optical flow analysis detected and quantified significant differences in the cell migrations of Sox10:EGFP positive cranial neural crest cells in ethanol treated versus untreated embryos.

  3. Sox10 might not be required for neural crest formation but is important for later steps during neural crest development.

  4. prdm1a (show PRDM1 Proteins) Regulates sox10 and islet1 (show ISL1 Proteins) in the development of neural crest and Rohon-Beard sensory neurons.

  5. Sox10 function is necessary for the survival of myelinating oligodedrocytes subsequent to axon wrapping but is not required for the survival of nonmyelinating oligodendrocyte progenitor cells.

  6. Phox2b (show PHOX2B Proteins) function is sox10-dependent in the developing enteric nervous system

  7. Decrement of function of foxd3 and/or sox10, two genes important for the development and specification of neural crest, resulted in a reduction and/or loss of GnRH cells of the midbrain, as well as a reduction in the number of terminal nerve GnRH cells.

  8. Data show that expression of Mitf (show MITF Proteins) rescues pigmentation fully in zebrafish, but only partially in Sox10-mutant mice.

  9. Sox10 is expressed transiently in the sensory neuron lineage, and specifies sensory neuron precursors by regulating the proneural gene neurogenin1 (show NEUROG1 Proteins).

  10. Sox10 has diverse roles in the otic vesicle that may be important in a zebrafish model for Waardenburg syndrome type IV

SOX10 Protein Profile

Protein Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

Gene names and symbols associated with SOX10

  • SoxE protein (soxE)
  • SRY (sex determining region Y)-box 10 (SOX10)
  • SRY (sex determining region Y)-box 10 (sox10)
  • transcription factor sox10 (sox10)
  • SRY (sex determining region Y)-box 10 (LOC100222412)
  • SRY (sex determining region Y)-box 10 (Sox10)
  • SRY-box containing gene 10 (Sox10)
  • SRY-box containing gene 10 (sox10)
  • cls/sox10 protein
  • Dom protein
  • PCWH protein
  • SOX-10 protein
  • SOX10 protein
  • Sox21 protein
  • soxE protein
  • WS2E protein
  • WS4 protein
  • WS4C protein
  • zgc:100757 protein

Protein level used designations for SOX10

SoxE protein , SRY (sex determining region Y)-box 10 , transcription factor Sox-10 , transcription factor SOX-10-like , transcription factor sox10 , SRY-related HMG-box gene 10 , dominant megacolon, mouse, human homolog of , transcription factor SOX-10 , SRY-box containing gene 10 , Sry-boxntranscription factor, SOX-10 , cSOX10 , SRY-box 10 , transcription factor Sox10 , dominant megacolon , transcription factor SOX-M , cls , colorless , colourless , colourless/sox10 , golas , gos , sox10b

GENE ID SPECIES
445804 Ciona intestinalis
470206 Pan troglodytes
481258 Canis lupus familiaris
702319 Macaca mulatta
100054980 Equus caballus
100101700 Xenopus (Silurana) tropicalis
100354496 Oryctolagus cuniculus
100404951 Callithrix jacchus
100534551 Oreochromis niloticus
100222412 Taeniopygia guttata
6663 Homo sapiens
29361 Rattus norvegicus
395573 Gallus gallus
414903 Sus scrofa
398422 Xenopus laevis
20665 Mus musculus
140616 Danio rerio
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