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SOX5 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX5 Antibodies (40) and SOX5 Kits (2) and many more products for this protein.
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Our results indicate for the first time that SOX5 is a novel regulator of epithelial-mesenchymal transition in hepatocellular carcinoma
Sox5-PAX5 (show PAX5 Proteins) fusion transcript is associated with B-cell precursor acute lymphoblastic leukemia.
Identified two new splice variants of SOX5 in human B cells, encoding the known L-SOX5B isoform and a new shorter isoform L-SOX5F. SOX5 limits the proliferative capacity of human primary B lymphocytes and potentially affects the differentiation of human B cells during the germinal center responses.
High Sox5 expression is associated with pituitary tumor.
detection of SOX5 polymorphism in nonobstructive azoospermia contributing to predicting males at high risk of disease in Han Chinese population
Sox5 and Sox9 (show SOX9 Proteins) cause a significant increase in transactivation of the Catsper1 (show CATSPER1 Proteins) promoter.
depletion of Sox5 in breast cancer cells caused a dramatic decrease in Twist1 (show TWIST1 Proteins) and chromosome immunoprecipitation assay showed that Sox5 can bind directly to the Twist1 (show TWIST1 Proteins) promoter, suggesting that Sox5 transactivates Twist1 (show TWIST1 Proteins) expression
Sox5 regulates the proliferation of malignant B cells.
Two cases of 12p12.1 deletion involving SOX5 present with dysmorphic features and developmental delay.
Our findings indicate that haploinsufficiency of SOX5 is a cause of intellectual disability without any striking physical anomalies.
show that Sox5 is essential for activation of BMP target genes in embryos and explants, that it physically interacts with BMP R-Smads
This study demonstrated that Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.
Results show that Sox9 (show SOX9 Proteins), Sox5, and Sox13 (show SOX13 Proteins) transcription factors are expressed in postnatal testis and may regulate multiple functions such as steroidogenesis and spermatogenesis.
Results suggest that L-Sox5 protein expression may diminish along with the progress of chondrogenic differentiation. L-Sox5 may act as a negative regulator if expressed aberrantly at least in part by regulating the critical fate of chondrogenesis.
T cell-specific Sox5-deficient mice exhibit impaired Th17 cell differentiation and are resistant to experimental autoimmune encephalomyelitis and delayed-type hypersensitivity.
L-Sox5 and Sox6 proteins enhance chondrogenic miR (show MLXIP Proteins)-140 microRNA expression by strengthening dimeric Sox9 (show SOX9 Proteins) activity
MiR (show MLXIP Proteins)-194 regulates chondrogenic differentiation of adipose-derived stem cells by targeting Sox5
Genetic variation in the transcription factor SOX5 is associated with COPD (show ARCN1 Proteins) susceptibility
SPAG6 (show SPAG6 Proteins) is a S-SOX5 target gene, indicating a key role for S-SOX5 in the formation and function of motile cilia.
These data suggest that synovial joint morphogenesis relies on essential roles for Sox5/6 in promoting both growth plate and articular chondrocyte differentiation.
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
transcription factor SOX-5
, SRY (sex determining region Y)-box 5
, Transcription factor Sox-5
, transcription factor LSox5-I
, SRY-box containing gene 5
, SRY-box containing gene 5-like 1
, SRY-box 5