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SRY (Sex Determining Region Y)-Box 8 Proteins (SOX8)

SOX8 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Additionally we are shipping SOX8 Antibodies (87) and SOX8 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SOX8 30812 P57073
Rat SOX8 SOX8 302993  
SOX8 20681 Q04886
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Top SOX8 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$3,290.83
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,325.67
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

SOX8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for SRY (Sex Determining Region Y)-Box 8 (SOX8) Interaction Partners

Human SRY (Sex Determining Region Y)-Box 8 (SOX8) interaction partners

  1. In non-small cell lung cancer, SOX8 expression was elevated, and correlated with tumor size, lymph node metastasis, clinical stage and differentiation classification.

  2. Suggest that miRNA-124 may regulate non-small cell lung carcinoma cell proliferation via decreasing SOX8.

  3. SOX8 mRNA levels decrease during in vitro dedifferentiation of human articular chondrocytes and increase during chondrogenic differentiation of mesenchymal stromal cells.

  4. SOX8 promotes cancer cell proliferation and its expression is correlated with elevated beta-catenin (show CTNNB1 Proteins) levels in hepatocellular carcinoma

  5. The SOX8 single nucleotide polymorphism, rs2744148, is associated with increased genetic risk for multiple sclerosis.

  6. Quantitative changes of enteric glia represented by SOX8 provide a basis for pathological assessment of glial proliferation and/or degeneration in the diseased gut (show GUSB Proteins).

  7. SOX2 (show SOX2 Proteins) and SOX17 (show SOX17 Proteins) expression patterns can distinguish between seminoma and embryonal carcinoma, and this distinction may be diagnostically useful.

Mouse (Murine) SRY (Sex Determining Region Y)-Box 8 (SOX8) interaction partners

  1. These results suggest that Sox8 is essential in Sertoli cells for germ cell differentiation, partly by controlling the microenvironment of the seminiferous epithelium.

  2. combined RNA profiling signals, motif predictions and network data identified putative SOX8/SOX9 (show SOX9 Proteins) target genes in Sertoli cells and yielded insight into regulatory interactions that depend upon these transcription factors

  3. Sox9 (show SOX9 Proteins) and Sox8 maintain integrity of the basal lamina to prevent testis cord disintegration and both factors actively suppress the ovarian program during early testis development.

  4. Seven regions near the Sox8 gene as potential enhancers, were identified.

  5. SOX8 has a role in testis differentiation in mice and synergizes with SF1 (show SF1 Proteins) to activate the Amh (show AMH Proteins) promoter in vitro

  6. Sox8 acts as a specific negative regulator of skeletal muscle differentiation, possibly by interfering with the function of myogenic basic helix-loop-helix proteins

  7. Results suggest that Sox8 reinforces Sox9 (show SOX9 Proteins) function in testis differentiation of mice.

  8. Sox8-deficient mice thus exhibited a similar, but less severe phenotype than did Sox10 (show SOX10 Proteins)-deficient mice wiwth regard to oligodendrocyte differentiation.

  9. The defects in enteric nervous system development of mice with Sox10 (show SOX10 Proteins) and Sox8 mutations are caused by a reduction of the pool of undifferentiated vagal neural crest cells.

  10. Sox8 is a negative regulator of osteoblast differentiation.

SOX8 Protein Profile

Protein Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).

Gene names and symbols associated with SOX8

  • SRY (sex determining region Y)-box 8 (SOX8)
  • SRY (sex determining region Y)-box 8 (Sox8)
  • SRY (sex determining region Y)-box 8 (sox8)
  • SRY-box containing gene 8 (Sox8)

Protein level used designations for SOX8

transcription factor SOX-8 , SRY-box containing gene 8 , transcription factor Sox-8 , SOX8 transcription factor

GENE ID SPECIES
30812 Homo sapiens
302993 Rattus norvegicus
399214 Xenopus laevis
490082 Canis lupus familiaris
395483 Gallus gallus
530317 Bos taurus
20681 Mus musculus
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